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Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?

  • Authors:
    • Giancarlo Tirelli
    • Laura Sidari
    • Vittorio Giacomarra
    • Ledia Papanikolla
    • Franco Sasso
    • Mario Russolo
    • Mauro Melato

  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/or.9.3.575
  • Pages: 575-580
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Abstract

Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-phase fraction. Our aim was to evaluate by flow cytometry both Ki67 and S-phase fraction, S + G2M, DNA content in patients surgically treated for oral cavity and/or oropharynx carcinomas. The study, performed on archival material, analysed the significance and prognostic reliability of these biological parameters to reveal locoregional metastasis and evaluated their possible correlation with clinical and histopathological parameters. In conclusion, tumour cell proliferation seems not to be useful in revealing the presence of locoregional metastasis in oral cavity and oropharynx carcinomas. Thus, new approaches are required.

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May-June 2002
Volume 9 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Tirelli G, Sidari L, Giacomarra V, Papanikolla L, Sasso F, Russolo M and Melato M: Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?. Oncol Rep 9: 575-580, 2002
APA
Tirelli, G., Sidari, L., Giacomarra, V., Papanikolla, L., Sasso, F., Russolo, M., & Melato, M. (2002). Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?. Oncology Reports, 9, 575-580. https://doi.org/10.3892/or.9.3.575
MLA
Tirelli, G., Sidari, L., Giacomarra, V., Papanikolla, L., Sasso, F., Russolo, M., Melato, M."Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?". Oncology Reports 9.3 (2002): 575-580.
Chicago
Tirelli, G., Sidari, L., Giacomarra, V., Papanikolla, L., Sasso, F., Russolo, M., Melato, M."Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?". Oncology Reports 9, no. 3 (2002): 575-580. https://doi.org/10.3892/or.9.3.575