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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2002 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review)

  • Authors:
    • Tomokazu Yoshizaki
    • Hiroshi Sato
    • Mitsuru Furukawa

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Graduate School of Medicine, Kanazawa 920-8641, Japan. tomoy@orl.m.kanazawa-u.ac.jp
  • Pages: 607-611
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/or.9.3.607
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Abstract

Matrix metalloproteinases (MMPs) play an important role in degradation of extracellular matrix (ECM), which is an essential step in the cascade of metastasis. Various types of MMPs are expressed and activated in head and neck squamous cell carcinoma (HNSCC) as well as other human cancers. MMP-2 is a prominent predictor of poor prognosis. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. In addition to the original role, recent studies show other important functions of MT1-MMP such as degradation of type I collagen and cleavage of CD44. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential for cell-mediated activation of MMP-2, and thus the contribution of TIMP-2 to tumor invasion has remained controversial. Some studies also suggested a role of TIMP-2 as a predictor of poor prognosis. Thus, inhibition of MMP activation by TIMPs is not a suitable strategy for suppressing invasion and metastasis. Instead of TIMP-2, various MMP inhibitors (MMPI) such as BB-2516 have been investigated with regard to suppression of tumor progression and improvement of prognosis in patients with advanced cancers, which resulted in no clinical efficacy. MMPs are especially important in the early stage of cancer progression, and thus strategies for future MMPI trials should be reconsidered.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshizaki T, Sato H and Furukawa M: Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review). Oncol Rep 9: 607-611, 2002.
APA
Yoshizaki, T., Sato, H., & Furukawa, M. (2002). Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review). Oncology Reports, 9, 607-611. https://doi.org/10.3892/or.9.3.607
MLA
Yoshizaki, T., Sato, H., Furukawa, M."Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review)". Oncology Reports 9.3 (2002): 607-611.
Chicago
Yoshizaki, T., Sato, H., Furukawa, M."Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review)". Oncology Reports 9, no. 3 (2002): 607-611. https://doi.org/10.3892/or.9.3.607
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshizaki T, Sato H and Furukawa M: Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review). Oncol Rep 9: 607-611, 2002.
APA
Yoshizaki, T., Sato, H., & Furukawa, M. (2002). Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review). Oncology Reports, 9, 607-611. https://doi.org/10.3892/or.9.3.607
MLA
Yoshizaki, T., Sato, H., Furukawa, M."Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review)". Oncology Reports 9.3 (2002): 607-611.
Chicago
Yoshizaki, T., Sato, H., Furukawa, M."Recent advances in the regulation of matrix metalloproteinase 2 activation: From basic research to clinical implication (Review)". Oncology Reports 9, no. 3 (2002): 607-611. https://doi.org/10.3892/or.9.3.607
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