Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats

  • Authors:
    • Masayuki Ohara
    • Huimei Lu
    • Katsutomo Shiraki
    • Yoshiyuki Ishimura
    • Toshihiro Uesaka
    • Osamu Katoh
    • Hiromitsu Watanabe
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/or.9.3.613
  • Pages: 613-616
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was designed to investigate the effects of fermented miso in the diet on the induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in male CD (SD) rats. A total of 120 animals, 6 weeks of age, were divided into 6 groups and given MNNG (100 ppm) in the drinking water for 16 weeks. Starting 1 week before the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 10% long-term fermented, medium- or short-term fermented miso, or 1% NaCl until the end of the MNNG exposure period. They were then maintained on the MF control diet and normal tap water until the autopsy time point at 52 weeks. The long-term fermented miso significantly reduced the size of the gastric tumors as compared with the other groups. The present results thus indicate that dietary supplementation with long-term fermented miso could act as a chemopreventive agent for gastric carcinogenesis.

Related Articles

Journal Cover

May-June 2002
Volume 9 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ohara M, Lu H, Shiraki K, Ishimura Y, Uesaka T, Katoh O and Watanabe H: Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats. Oncol Rep 9: 613-616, 2002
APA
Ohara, M., Lu, H., Shiraki, K., Ishimura, Y., Uesaka, T., Katoh, O., & Watanabe, H. (2002). Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats. Oncology Reports, 9, 613-616. https://doi.org/10.3892/or.9.3.613
MLA
Ohara, M., Lu, H., Shiraki, K., Ishimura, Y., Uesaka, T., Katoh, O., Watanabe, H."Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats". Oncology Reports 9.3 (2002): 613-616.
Chicago
Ohara, M., Lu, H., Shiraki, K., Ishimura, Y., Uesaka, T., Katoh, O., Watanabe, H."Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats". Oncology Reports 9, no. 3 (2002): 613-616. https://doi.org/10.3892/or.9.3.613