Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue

  • Authors:
    • Kyoko Yoneda
    • Ayako Tomimoto
    • Hiroki Endo
    • Hiroshi Iida
    • Michiko Sugiyama
    • Hirokazu Takahashi
    • Hironori Mawatari
    • Yuichi Nozaki
    • Koji Fujita
    • Masato Yoneda
    • Masahiko Inamori
    • Noriko Nakajima
    • Koichiro Wada
    • Yoji Nagashima
    • Hitoshi Nakagama
    • Hitoshi Uozaki
    • Masashi Fukayama
    • Atsushi Nakajima
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/or_00000031
  • Pages: 479-483
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Abstract

Adiponectin is secreted by adipocytes and is a key hormone responsible for insulin sensitization. Recent studies have shown that plasma adiponectin is decreased in patients with breast, endometrial and gastric cancer. However, the effect of adiponectin on colorectal carcinogenesis is controversial. It is now well known that the adiponectin receptor exists in two isoforms, adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). We examined the expression of the adiponectin receptors on normal colon mucosa and colon cancer tissues in a human study using real-time RT-PCR, Western blotting and immunohistochemical staining. Adiponectin receptors, AdipoR1/AdipoR2, were expressed in normal colon epithelial and colon cancer cells. Furthermore, laser microdissection was performed to confirm our results. These results suggest that adiponectin may exert some effects on normal colon epithelium or colon cancer cells directly through adiponectin receptors. Further studies are required to elucidate the function of the AdipoRs activated by adiponectin and the downstream mechanisms of AdipoRs in colon cancer cells.

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September 2008
Volume 20 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Yoneda M, et al: Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncol Rep 20: 479-483, 2008.
APA
Yoneda, K., Tomimoto, A., Endo, H., Iida, H., Sugiyama, M., Takahashi, H. ... Nakajima, A. (2008). Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncology Reports, 20, 479-483. https://doi.org/10.3892/or_00000031
MLA
Yoneda, K., Tomimoto, A., Endo, H., Iida, H., Sugiyama, M., Takahashi, H., Mawatari, H., Nozaki, Y., Fujita, K., Yoneda, M., Inamori, M., Nakajima, N., Wada, K., Nagashima, Y., Nakagama, H., Uozaki, H., Fukayama, M., Nakajima, A."Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue". Oncology Reports 20.3 (2008): 479-483.
Chicago
Yoneda, K., Tomimoto, A., Endo, H., Iida, H., Sugiyama, M., Takahashi, H., Mawatari, H., Nozaki, Y., Fujita, K., Yoneda, M., Inamori, M., Nakajima, N., Wada, K., Nagashima, Y., Nakagama, H., Uozaki, H., Fukayama, M., Nakajima, A."Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue". Oncology Reports 20, no. 3 (2008): 479-483. https://doi.org/10.3892/or_00000031