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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article

Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas

  • Authors:
    • Haiyan Li
    • Qun Wang
    • Fei Gao
    • Faliang Zhu
    • Xiaoyan Wang
    • Chengjun Zhou
    • Chunmei Liu
    • Yingyu Chen
    • Chunhong Ma
    • Wensheng Sun
    • Lining Zhang

  • View Affiliations / Copyright

    Affiliations: Institute of Immunology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 573-579
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000044
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Abstract

Programmed cell death 5 (PDCD5) is a novel apoptosis-promoting protein. Recently, a decreased expression of PDCD5 has been found in several types of human tumors. However, the expression level of PDCD5 in human gliomas has not been investigated. In the present study, we examined the expression of PDCD5 in 88 human glioma samples at both mRNA and protein levels by RT-PCR, Western blotting and immunohistochemistry. We found that 53.3% (16/30) of the glioma samples had a reduced expression of PDCD5 mRNA and 70.5% (62/88) had a reduced expression of the PDCD5 protein as compared to normal brain tissue. Furthermore, we studied the correlation of the expression level of PDCD5 with the clinicopathological grade and survival of patients with astrocytomas. Although longitudinal studies of a cohort of patients with astrocytoma revealed that PDCD5 expression was not able to predict clinical outcome (p>0.05), a decreased expression of PDCD5 correlated significantly with high-grade astrocytomas (p<0.001). In conclusion, our data suggest that reduced PDCD5 expression may contribute to the pathogenesis of human gliomas.

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Wang Q, Gao F, Zhu F, Wang X, Zhou C, Liu C, Chen Y, Ma C, Sun W, Sun W, et al: Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncol Rep 20: 573-579, 2008.
APA
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C. ... Zhang, L. (2008). Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncology Reports, 20, 573-579. https://doi.org/10.3892/or_00000044
MLA
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C., Liu, C., Chen, Y., Ma, C., Sun, W., Zhang, L."Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas". Oncology Reports 20.3 (2008): 573-579.
Chicago
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C., Liu, C., Chen, Y., Ma, C., Sun, W., Zhang, L."Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas". Oncology Reports 20, no. 3 (2008): 573-579. https://doi.org/10.3892/or_00000044
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Wang Q, Gao F, Zhu F, Wang X, Zhou C, Liu C, Chen Y, Ma C, Sun W, Sun W, et al: Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncol Rep 20: 573-579, 2008.
APA
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C. ... Zhang, L. (2008). Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncology Reports, 20, 573-579. https://doi.org/10.3892/or_00000044
MLA
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C., Liu, C., Chen, Y., Ma, C., Sun, W., Zhang, L."Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas". Oncology Reports 20.3 (2008): 573-579.
Chicago
Li, H., Wang, Q., Gao, F., Zhu, F., Wang, X., Zhou, C., Liu, C., Chen, Y., Ma, C., Sun, W., Zhang, L."Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas". Oncology Reports 20, no. 3 (2008): 573-579. https://doi.org/10.3892/or_00000044
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