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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article

Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1

  • Authors:
    • Yifei Du
    • Shuangyue Zhang
    • Zilu Wang
    • Weina Zhou
    • Mingliang Luan
    • Xiaohan Yang
    • Ning Chen

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, School of Stomatology, Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 605-611
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000048
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Abstract

Overexpression of cyclooxygenase-2 (COX-2) plays an important role in development and progression of different human cancers, but the underlying molecular mechanisms remain to be defined. Tissue specimens of normal oral epithelia (n=9), dysplasia (n=38), and oral squamous cell carcinoma (SCC, n=54) were immunohistochemically analyzed for COX-2 and E2F-1 expression. A human oral SCC cell line, Tca8113, was used to assess NS398 antitumor activity. PGE2 levels were measured by using radioimmunoassay, and COX-2, pRb, and E2F-1 proteins were determined by Western blot assay. We found expression of COX-2 and E2F-1 proteins was significantly increased in both oral dysplasia and SCC compared to the normal epithelium. Increased COX-2 expression was associated with E2F-1 expression in both oral dysplasia and SCC. NS398 treatment reduced viability of Tca8113 cells in a dose- and time-dependent manner. NS398 suppressed PGE2 levels, a product of COX-2 enzyme, in the tumor cells. The reduced cell viability is due to induction of apoptosis by NS398, which activates caspase-3, but does not inhibit bcl-2. NS398 also induced tumor cell arrest at G1 phase of the cell cycle and inhibited expression of COX-2, pRb and E2F-1 proteins. This study provides evidence that E2F-1 and COX-2 are overexpressed in oral cancer, and further supports suppression of COX-2 in control of oral cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Du Y, Zhang S, Wang Z, Zhou W, Luan M, Yang X and Chen N: Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncol Rep 20: 605-611, 2008.
APA
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., & Chen, N. (2008). Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncology Reports, 20, 605-611. https://doi.org/10.3892/or_00000048
MLA
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., Chen, N."Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1". Oncology Reports 20.3 (2008): 605-611.
Chicago
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., Chen, N."Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1". Oncology Reports 20, no. 3 (2008): 605-611. https://doi.org/10.3892/or_00000048
Copy and paste a formatted citation
x
Spandidos Publications style
Du Y, Zhang S, Wang Z, Zhou W, Luan M, Yang X and Chen N: Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncol Rep 20: 605-611, 2008.
APA
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., & Chen, N. (2008). Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncology Reports, 20, 605-611. https://doi.org/10.3892/or_00000048
MLA
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., Chen, N."Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1". Oncology Reports 20.3 (2008): 605-611.
Chicago
Du, Y., Zhang, S., Wang, Z., Zhou, W., Luan, M., Yang, X., Chen, N."Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1". Oncology Reports 20, no. 3 (2008): 605-611. https://doi.org/10.3892/or_00000048
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