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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article

Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases

  • Authors:
    • Ute Warnecke-Eberz
    • Elfriede Bollschweiler
    • Uta Drebber
    • Alexandra Pohl
    • Stephan E. Baldus
    • Arnulf H. Hoelscher
    • Ralf Metzger

  • View Affiliations / Copyright

    Affiliations: Department of Visceral and Vascular Surgery, Laboratory for Molecular Oncology, University of Cologne, D-50937 Cologne, Germany. ute.warnecke-eberz@uk-koeln.de
  • Pages: 619-624
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000050
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Abstract

Pim kinases are emerging as important mediators of cytokine signalling pathways in hematopoietic cells, and contribute to the progression of certain leukemias and solid tumors. The mRNA expression of pim-1, a putative oncogenic serine-threonine kinase, was determined in non-small cell lung cancer (NSCLC) patients. Sixty-eight patients with potentially curative resections (R0 resections) for NSCLC in histopathological stages I-IIIA were included. An analysis of pim-1 mRNA expression was performed on paired tumor and normal lung tissue samples by quantitative real-time reverse transcriptase-PCR (RT-PCR) standardized for β-actin. Pim-1 expression in the tumor (median 0.28) was significantly down-regulated (p<0.0001) compared to the paired normal tissue (median 4.96). Immunohistochemistry showed a strong expression of Pim-1 protein in the normal respiratory epithelium and a lower expression in the tumor cells. A significant association between the pim-1 down-regulation and occurrence of lymph node metastases (p=0.05) was detected. The down-regulation of pim-1 mRNA was demonstrated for 59 out of 68 lung cancer patients (86.8%). Down-regulation occurs already in the early stage of NSCLC and is either directly involved in the lymphatic progression in NSCLC or represents a surrogate marker.

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Copy and paste a formatted citation
Spandidos Publications style
Warnecke-Eberz U, Bollschweiler E, Drebber U, Pohl A, Baldus SE, Hoelscher AH and Metzger R: Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncol Rep 20: 619-624, 2008.
APA
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S.E., Hoelscher, A.H., & Metzger, R. (2008). Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncology Reports, 20, 619-624. https://doi.org/10.3892/or_00000050
MLA
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S. E., Hoelscher, A. H., Metzger, R."Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases". Oncology Reports 20.3 (2008): 619-624.
Chicago
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S. E., Hoelscher, A. H., Metzger, R."Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases". Oncology Reports 20, no. 3 (2008): 619-624. https://doi.org/10.3892/or_00000050
Copy and paste a formatted citation
x
Spandidos Publications style
Warnecke-Eberz U, Bollschweiler E, Drebber U, Pohl A, Baldus SE, Hoelscher AH and Metzger R: Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncol Rep 20: 619-624, 2008.
APA
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S.E., Hoelscher, A.H., & Metzger, R. (2008). Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases. Oncology Reports, 20, 619-624. https://doi.org/10.3892/or_00000050
MLA
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S. E., Hoelscher, A. H., Metzger, R."Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases". Oncology Reports 20.3 (2008): 619-624.
Chicago
Warnecke-Eberz, U., Bollschweiler, E., Drebber, U., Pohl, A., Baldus, S. E., Hoelscher, A. H., Metzger, R."Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases". Oncology Reports 20, no. 3 (2008): 619-624. https://doi.org/10.3892/or_00000050
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