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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article

Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells

  • Authors:
    • Yong Hwan Han
    • Suhn Hee Kim
    • Sung Zoo Kim
    • Woo Hyun Park

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Medical School, Institute for Medical Sciences, Centers for Healthcare Technology Development, Chonbuk National University, JeonJu 561-180, Republic of Korea
  • Pages: 689-693
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000061
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Abstract

Antimycin A (AMA) inhibits mitochondrial electron transport between cytochromes b and c. We evaluated the effects of AMA on the growth of human pulmonary adenocarcinoma A549 cells in relation to cell cycle and apoptosis. Treatment with 2-100 µM AMA significantly inhibited the cell growth of A549 for 72 h. DNA flow cytometry indicated that AMA slightly induced a G1 phase arrest of the cell cycle for 72 h. Treatment with 50 µM AMA induced apoptosis of ≈17% in view of annexin V-staining cells. The dose of 50 µM AMA also induced loss of the mitochondrial membrane potential (ΔΨm) of ≈38%. The intracellular reactive oxygen species (ROS) levels including O2·−- were significantly increased in AMA-treated A549 cells. In conclusion, AMA inhibited the growth of A549 cells via inducing cell cycle arrest as well as triggering apoptosis. Growth inhibition in AMA-treated A549 cells was accompanied by an increase in ROS levels.

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Copy and paste a formatted citation
Spandidos Publications style
Han YH, Kim SH, Kim SZ and Park WH: Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncol Rep 20: 689-693, 2008.
APA
Han, Y.H., Kim, S.H., Kim, S.Z., & Park, W.H. (2008). Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncology Reports, 20, 689-693. https://doi.org/10.3892/or_00000061
MLA
Han, Y. H., Kim, S. H., Kim, S. Z., Park, W. H."Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells". Oncology Reports 20.3 (2008): 689-693.
Chicago
Han, Y. H., Kim, S. H., Kim, S. Z., Park, W. H."Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells". Oncology Reports 20, no. 3 (2008): 689-693. https://doi.org/10.3892/or_00000061
Copy and paste a formatted citation
x
Spandidos Publications style
Han YH, Kim SH, Kim SZ and Park WH: Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncol Rep 20: 689-693, 2008.
APA
Han, Y.H., Kim, S.H., Kim, S.Z., & Park, W.H. (2008). Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncology Reports, 20, 689-693. https://doi.org/10.3892/or_00000061
MLA
Han, Y. H., Kim, S. H., Kim, S. Z., Park, W. H."Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells". Oncology Reports 20.3 (2008): 689-693.
Chicago
Han, Y. H., Kim, S. H., Kim, S. Z., Park, W. H."Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells". Oncology Reports 20, no. 3 (2008): 689-693. https://doi.org/10.3892/or_00000061
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