Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9

  • Authors:
    • Kazuhiko Hatate
    • Keishi Yamashita
    • Kazuya Hirai
    • Hiroshi Kumamoto
    • Takeo Sato
    • Heita Ozawa
    • Takatoshi Nakamura
    • Wataru Onozato
    • Yukihito Kokuba
    • Atsushi Ihara
    • Masahiko Watanabe
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/or_00000068
  • Pages: 737-743
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Abstract

Phosphatase of regenerating liver (PRL)-3 was identified as a molecule associated with liver metastasis in colorectal cancer (CRC), although its precise causative role in distant metastasis remains elusive from a clinical point of view. The aim of this study was to promote the mechanistic insight of PRL-3 involvement in liver metastasis in CRC. One hundred and seven CRC patients with resection of the primary lesions were studied for clinicopathological and prognostic association with PRL-3 and were evaluated by immunohistochemistry in univariate and multivariate analyses. Intense immunostaining of PRL-3 was found in Dukes' A (0/26), Dukes' B (0/30), Dukes' C (18/30) and Duke's D (20/21) although the PRL-3 expression could not predict metachronous liver metastasis (MLM) in Dukes' C patients. PRL-3 expression showed an inverse correlation of prognosis in a univariate prognostic analysis (P<0.0001), though a multivariate assay failed to demonstrate PRL-3 relevance as an independent prognostic factor. PRL-3 expression was closely associated with classic prognostic factors such as the pN factor (P<0.0001), H factor-synchronous liver metastasis (SLM) (P<0.0001), pT factor (P=0.0002), preoperative CEA (P<0.0001) and preoperative CA19-9 (P<0.0001). Multivariate logistic regression analysis of PRL-3 expression revealed that the pN factor (P<0.0001), CEA (P<0.0001) and CA19-9 (P<0.0001) were finally remnant as an independent association with PRL-3. However, the H factor (SLM) was eliminated. Our data suggested that liver metastasis by PRL-3 is putatively mediated through lymph node metastasis and elevated tumor markers in the serum and the PRL-3 expression may not represent a direct causative mechanism of liver metastasis.

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October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hatate K, Yamashita K, Hirai K, Kumamoto H, Sato T, Ozawa H, Nakamura T, Onozato W, Kokuba Y, Ihara A, Ihara A, et al: Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9. Oncol Rep 20: 737-743, 2008.
APA
Hatate, K., Yamashita, K., Hirai, K., Kumamoto, H., Sato, T., Ozawa, H. ... Watanabe, M. (2008). Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9. Oncology Reports, 20, 737-743. https://doi.org/10.3892/or_00000068
MLA
Hatate, K., Yamashita, K., Hirai, K., Kumamoto, H., Sato, T., Ozawa, H., Nakamura, T., Onozato, W., Kokuba, Y., Ihara, A., Watanabe, M."Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9". Oncology Reports 20.4 (2008): 737-743.
Chicago
Hatate, K., Yamashita, K., Hirai, K., Kumamoto, H., Sato, T., Ozawa, H., Nakamura, T., Onozato, W., Kokuba, Y., Ihara, A., Watanabe, M."Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9". Oncology Reports 20, no. 4 (2008): 737-743. https://doi.org/10.3892/or_00000068