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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 20 Issue 4

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Article

Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways

  • Authors:
    • Jian-Li Gao
    • Jun-Min Shi
    • Kai He
    • Qing-Wen Zhang
    • Shao-Ping Li
    • Simon Ming-Yuen Lee
    • Yi-Tao Wang

  • View Affiliations / Copyright

    Affiliations: Institute of Chinese Medical Sciences, University of Macau, Macau 999078, P.R. China
  • Pages: 819-824
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000079
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Abstract

Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM). In this study, we attempted to characterize in detail the signaling cascades that produce its anti-metastatic effect on the human breast cancer cell line, MDA-MB-231. We found that the yanhusuo extract inhibited the migration and invasion of MDA-MB-231 cells in vitro. In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). The anti-cancer metastasis effect of yanhusuo involved the activation of p38 and inhibition of ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling. Our experiments identified the biological activity of yanhusuo against cancer metastasis in vitro and provide a rationale for its further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
Gao J, Shi J, He K, Zhang Q, Li S, Lee SM and Wang Y: Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep 20: 819-824, 2008.
APA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S.M., & Wang, Y. (2008). Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncology Reports, 20, 819-824. https://doi.org/10.3892/or_00000079
MLA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20.4 (2008): 819-824.
Chicago
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20, no. 4 (2008): 819-824. https://doi.org/10.3892/or_00000079
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Shi J, He K, Zhang Q, Li S, Lee SM and Wang Y: Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep 20: 819-824, 2008.
APA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S.M., & Wang, Y. (2008). Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncology Reports, 20, 819-824. https://doi.org/10.3892/or_00000079
MLA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20.4 (2008): 819-824.
Chicago
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20, no. 4 (2008): 819-824. https://doi.org/10.3892/or_00000079
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