Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways

  • Authors:
    • Jian-Li Gao
    • Jun-Min Shi
    • Kai He
    • Qing-Wen Zhang
    • Shao-Ping Li
    • Simon Ming-Yuen Lee
    • Yi-Tao Wang
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/or_00000079
  • Pages: 819-824
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Abstract

Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM). In this study, we attempted to characterize in detail the signaling cascades that produce its anti-metastatic effect on the human breast cancer cell line, MDA-MB-231. We found that the yanhusuo extract inhibited the migration and invasion of MDA-MB-231 cells in vitro. In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). The anti-cancer metastasis effect of yanhusuo involved the activation of p38 and inhibition of ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling. Our experiments identified the biological activity of yanhusuo against cancer metastasis in vitro and provide a rationale for its further investigation.

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October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gao J, Shi J, He K, Zhang Q, Li S, Lee SM and Wang Y: Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep 20: 819-824, 2008
APA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S.M., & Wang, Y. (2008). Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncology Reports, 20, 819-824. https://doi.org/10.3892/or_00000079
MLA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20.4 (2008): 819-824.
Chicago
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20, no. 4 (2008): 819-824. https://doi.org/10.3892/or_00000079