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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma

  • Authors:
    • António E. Pinto
    • Giovani Silva
    • Ana Banito
    • Valeriano Leite
    • Jorge Soares

  • View Affiliations / Copyright

    Affiliations: Serviço de Anatomia Patológica, Instituto Português Oncologia de Lisboa, E.P.E., 1099-023 Lisbon, Portugal. aepinto@ipolisboa.min-saude.pt
  • Pages: 913-919
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000091
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Abstract

This study aimed to investigate the prognostic influence of DNA flow cytometry and RAS gene mutations in patients with poorly differentiated (PDTC) and anaplastic thyroid carcinoma (ATC). The series consisted of 26 patients with PDTC and ATC, and a median follow-up of 10 months (range 1-138). DNA ploidy and S-phase fraction (SPF) were assessed by flow cytometry on frozen samples. RAS point mutations were detected using PCR techniques. Disease staging and tumour angioinvasion were included as prognostic parameters for survival analysis. Nineteen patients (73.1%) succumbed to the disease (median time 5 months; range 1-45). Eighteen tumours (69.2%) were classified as DNA aneuploid. Median SPF was 5.6% (range 1.9-23.1), which was used as a cut-off value to distinguish between low versus high cell proliferation. Three of 20 (15%) patients presented N-RAS gene mutations in codon 61. DNA aneuploidy was most frequently found in female patients (p=0.034). Kaplan-Meier and Cox regression analyses showed that only DNA aneuploidy (p=0.044 and p=0.055, respectively) and high SPF (p=0.001 and p=0.006, respectively) significantly correlated with worse survival. The results indicate that aneuploidy and high SPF are biomarkers of poor clinical outcome in PDTC and ATC, which may provide useful prognostic information with a potentially therapeutic impact in patient management.

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Copy and paste a formatted citation
Spandidos Publications style
Pinto AE, Silva G, Banito A, Leite V and Soares J: Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncol Rep 20: 913-919, 2008.
APA
Pinto, A.E., Silva, G., Banito, A., Leite, V., & Soares, J. (2008). Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncology Reports, 20, 913-919. https://doi.org/10.3892/or_00000091
MLA
Pinto, A. E., Silva, G., Banito, A., Leite, V., Soares, J."Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma". Oncology Reports 20.4 (2008): 913-919.
Chicago
Pinto, A. E., Silva, G., Banito, A., Leite, V., Soares, J."Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma". Oncology Reports 20, no. 4 (2008): 913-919. https://doi.org/10.3892/or_00000091
Copy and paste a formatted citation
x
Spandidos Publications style
Pinto AE, Silva G, Banito A, Leite V and Soares J: Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncol Rep 20: 913-919, 2008.
APA
Pinto, A.E., Silva, G., Banito, A., Leite, V., & Soares, J. (2008). Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncology Reports, 20, 913-919. https://doi.org/10.3892/or_00000091
MLA
Pinto, A. E., Silva, G., Banito, A., Leite, V., Soares, J."Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma". Oncology Reports 20.4 (2008): 913-919.
Chicago
Pinto, A. E., Silva, G., Banito, A., Leite, V., Soares, J."Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma". Oncology Reports 20, no. 4 (2008): 913-919. https://doi.org/10.3892/or_00000091
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