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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 20 Issue 5

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Article

LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma

  • Authors:
    • Yu Yang
    • Hua Yang
    • Michael A. McNutt
    • Fuxia Xiong
    • Xiu Nie
    • Li Li
    • Rouli Zhou

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Peking University Health Science Center, Beijing 100083, P.R. China
  • Pages: 1077-1083
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000112
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Abstract

Lysosome-associated protein transmembrane 4β (LAPTM4B) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is strongly expressed in some solid malignancies. The present study investigated the correlation of LAPTM4B expression with clinicopathological features and prognosis in ovarian carcinoma. Expression of LAPTM4B was evaluated semiquantitatively by immunohistochemistry in 85 cases of ovarian carcinoma. High LAPTM4B expression was found in 54 (63.5%) of these 85 carcinomas, and was positively correlated with FIGO stage, histological subtype and residual tumor after primary surgery, but not with age and tumor grade. Patients with high LAPTM4B expression had significantly poorer overall survival (OS) and progression-free survival (PFS) (P<0.001 and P<0.001, respectively) compared to patients with low expression of LAPTM4B. On multivariate analysis, LAPTM4B expression was found to be an independent prognostic factor for OS and PFS (P=0.01 and P=0.03, respectively). These results showed that high LAPTM4B expression was associated with progression of ovarian carcinoma and correlated with unfavorable clinical outcome, suggesting that LAPTM4B may be a clinically useful prognostic indicator for ovarian carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Yang H, McNutt MA, Xiong F, Nie X, Li L and Zhou R: LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep 20: 1077-1083, 2008.
APA
Yang, Y., Yang, H., McNutt, M.A., Xiong, F., Nie, X., Li, L., & Zhou, R. (2008). LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncology Reports, 20, 1077-1083. https://doi.org/10.3892/or_00000112
MLA
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20.5 (2008): 1077-1083.
Chicago
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20, no. 5 (2008): 1077-1083. https://doi.org/10.3892/or_00000112
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Yang H, McNutt MA, Xiong F, Nie X, Li L and Zhou R: LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep 20: 1077-1083, 2008.
APA
Yang, Y., Yang, H., McNutt, M.A., Xiong, F., Nie, X., Li, L., & Zhou, R. (2008). LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncology Reports, 20, 1077-1083. https://doi.org/10.3892/or_00000112
MLA
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20.5 (2008): 1077-1083.
Chicago
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20, no. 5 (2008): 1077-1083. https://doi.org/10.3892/or_00000112
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