LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma

  • Authors:
    • Yu Yang
    • Hua Yang
    • Michael A. McNutt
    • Fuxia Xiong
    • Xiu Nie
    • Li Li
    • Rouli Zhou
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/or_00000112
  • Pages: 1077-1083
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Abstract

Lysosome-associated protein transmembrane 4β (LAPTM4B) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is strongly expressed in some solid malignancies. The present study investigated the correlation of LAPTM4B expression with clinicopathological features and prognosis in ovarian carcinoma. Expression of LAPTM4B was evaluated semiquantitatively by immunohistochemistry in 85 cases of ovarian carcinoma. High LAPTM4B expression was found in 54 (63.5%) of these 85 carcinomas, and was positively correlated with FIGO stage, histological subtype and residual tumor after primary surgery, but not with age and tumor grade. Patients with high LAPTM4B expression had significantly poorer overall survival (OS) and progression-free survival (PFS) (P<0.001 and P<0.001, respectively) compared to patients with low expression of LAPTM4B. On multivariate analysis, LAPTM4B expression was found to be an independent prognostic factor for OS and PFS (P=0.01 and P=0.03, respectively). These results showed that high LAPTM4B expression was associated with progression of ovarian carcinoma and correlated with unfavorable clinical outcome, suggesting that LAPTM4B may be a clinically useful prognostic indicator for ovarian carcinoma.

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November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yang Y, Yang H, McNutt MA, Xiong F, Nie X, Li L and Zhou R: LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep 20: 1077-1083, 2008
APA
Yang, Y., Yang, H., McNutt, M.A., Xiong, F., Nie, X., Li, L., & Zhou, R. (2008). LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncology Reports, 20, 1077-1083. https://doi.org/10.3892/or_00000112
MLA
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20.5 (2008): 1077-1083.
Chicago
Yang, Y., Yang, H., McNutt, M. A., Xiong, F., Nie, X., Li, L., Zhou, R."LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma". Oncology Reports 20, no. 5 (2008): 1077-1083. https://doi.org/10.3892/or_00000112