Two cases with clavicula pro humero reconstruction are described after extensive extraarticular wide resection of osteosarcoma due to the aggressive invasion, pre-operative pathological fracture, and relatively resistant to preoperative chemotherapy. Each patient had proximal humeral osteosarcoma and needed extraarticular resection. One necessitated more than two-third of humeral resection and reconstructed with rotated clavicle reconstruction with use of pasteurized intercalary autogenous bone graft. The other necessitated wide scapular resection, preserving acromio-clavicular joint, could be reconstructed with rotated clavicle. Both had soft tissue reconstruction with pedicled lattissimus dorsi muscle flap for soft tissue defect. The Musculoskeletal Tumor Society score was 73% and 87%, comparable for a previous report with clavicle pro humero reconstruction after conventional resection of proximal humerus or other reconstructive procedures. One had postoperative complication of prominent acromion with skin perforation. Both patients are alive with no evidence of disease, and no local recurrence. Clavicula pro humero reconstruction should be considered in selected patients for whom acromio-clavicular joint could be preserved after extensive resection of humerus or glenoid to obtain wide surgical margin.

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