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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis

  • Authors:
    • Marco Artico
    • Elena Bronzetti
    • Laura M. Felici
    • Valentina Alicino
    • Brunella Ionta
    • Benedetto Bronzetti
    • Giuseppe Magliulo
    • Claudia Grande
    • Loris Zamai
    • Guido Pasquantonio
    • Marco De Vincentiis

  • View Affiliations / Copyright

    Affiliations: Giorgio Ferreri Department of Otorhinolaryngology, Audiology, and Phoniatry, University of Rome ‘La Sapienza’, I-00185 Rome, Italy
  • Pages: 1201-1206
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000130
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Abstract

Lymphoid organs are supplied by many nerve endings associated with different kinds of cells and macrophages. The role of this innervation on the release of locally active molecules is still unclear. Lingual tonsils belong to Waldeyer's Ring, in close association with palatine tonsils and nasopharyngeal (adenoids) tonsils, thus constituting part of NALT (nasal-associated lymphoid tissue) together with the tubal tonsils and lateral pharyngeal bands. In this study, we focused our attention on the expression of some neurotrophins (NTs) and their high- and low-affinity receptors in human lingual tonsils. Light immunohistochemistry showed that human tonsillar samples were generally positive for all the NTs investigated (NGF, BDNF, NT-3, NT-4) and their receptors (TrKA, TrKB, TrKC and p75) with some different expression levels. NGF and TrKC were strongly expressed in macrophages, but weakly in lymphocytes. However, BDNF and TrKB was highly expressed in lymphocytes and weaker in macrophages. The low-affinity receptor for NGF, p75, was mainly moderately expressed in the analysed samples. These results suggest the presence of a pattern of neurotrophin innervation in the human lingual tonsil which may play a role in sustaining inflammatory conditions and in modulating a close interaction between the nervous system and the different immune cellular subtypes.

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Copy and paste a formatted citation
Spandidos Publications style
Artico M, Bronzetti E, Felici LM, Alicino V, Ionta B, Bronzetti B, Magliulo G, Grande C, Zamai L, Pasquantonio G, Pasquantonio G, et al: Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis. Oncol Rep 20: 1201-1206, 2008.
APA
Artico, M., Bronzetti, E., Felici, L.M., Alicino, V., Ionta, B., Bronzetti, B. ... De Vincentiis, M. (2008). Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis. Oncology Reports, 20, 1201-1206. https://doi.org/10.3892/or_00000130
MLA
Artico, M., Bronzetti, E., Felici, L. M., Alicino, V., Ionta, B., Bronzetti, B., Magliulo, G., Grande, C., Zamai, L., Pasquantonio, G., De Vincentiis, M."Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis". Oncology Reports 20.5 (2008): 1201-1206.
Chicago
Artico, M., Bronzetti, E., Felici, L. M., Alicino, V., Ionta, B., Bronzetti, B., Magliulo, G., Grande, C., Zamai, L., Pasquantonio, G., De Vincentiis, M."Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis". Oncology Reports 20, no. 5 (2008): 1201-1206. https://doi.org/10.3892/or_00000130
Copy and paste a formatted citation
x
Spandidos Publications style
Artico M, Bronzetti E, Felici LM, Alicino V, Ionta B, Bronzetti B, Magliulo G, Grande C, Zamai L, Pasquantonio G, Pasquantonio G, et al: Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis. Oncol Rep 20: 1201-1206, 2008.
APA
Artico, M., Bronzetti, E., Felici, L.M., Alicino, V., Ionta, B., Bronzetti, B. ... De Vincentiis, M. (2008). Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis. Oncology Reports, 20, 1201-1206. https://doi.org/10.3892/or_00000130
MLA
Artico, M., Bronzetti, E., Felici, L. M., Alicino, V., Ionta, B., Bronzetti, B., Magliulo, G., Grande, C., Zamai, L., Pasquantonio, G., De Vincentiis, M."Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis". Oncology Reports 20.5 (2008): 1201-1206.
Chicago
Artico, M., Bronzetti, E., Felici, L. M., Alicino, V., Ionta, B., Bronzetti, B., Magliulo, G., Grande, C., Zamai, L., Pasquantonio, G., De Vincentiis, M."Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis". Oncology Reports 20, no. 5 (2008): 1201-1206. https://doi.org/10.3892/or_00000130
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