Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy

  • Authors:
    • Zhouzhou Zhao
    • Di Wang
    • Chengang Zhu
    • Huanjie Shao
    • Chong Sun
    • Hongling Qiu
    • Lu Xue
    • Junhua Xu
    • Mingxiong Guo
    • Wenxin Li
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/or_00000136
  • Pages: 1243-1248
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Abstract

The human ZNF268 gene was initially described as a gene associated with early human embryogenesis and was later implicated in human leukemia due to the identification of an alternatively splice form in leukemia patients. To systematically evaluate the correlation of ZNF268 with human hematological malignancy, expression of different alternatively spliced forms of ZNF268 mRNA in peripheral blood of 45 patients with hematological malignancies and 17 healthy donors were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and nested PCR. We demonstrated that presence of ZNF268a, ZNF268c, ZNF268f and ZNF268g were significantly different between the patients and healthy donors (P<0.05). Our study thus suggests that aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies.

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November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhao Z, Wang D, Zhu C, Shao H, Sun C, Qiu H, Xue L, Xu J, Guo M, Li W, Li W, et al: Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncol Rep 20: 1243-1248, 2008
APA
Zhao, Z., Wang, D., Zhu, C., Shao, H., Sun, C., Qiu, H. ... Li, W. (2008). Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncology Reports, 20, 1243-1248. https://doi.org/10.3892/or_00000136
MLA
Zhao, Z., Wang, D., Zhu, C., Shao, H., Sun, C., Qiu, H., Xue, L., Xu, J., Guo, M., Li, W."Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy". Oncology Reports 20.5 (2008): 1243-1248.
Chicago
Zhao, Z., Wang, D., Zhu, C., Shao, H., Sun, C., Qiu, H., Xue, L., Xu, J., Guo, M., Li, W."Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy". Oncology Reports 20, no. 5 (2008): 1243-1248. https://doi.org/10.3892/or_00000136