Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer

Ito,Isao; Mukai,Masaya; Ninomiya,Hiromi; Kishima,Kyoko; Tsuchiya,Kazutoshi; Tajima,Takayuki; Nakamura,Masato; Makuuchi,Hiroyasu

doi:10.3892/or_00000174

December 2008 Volume 20 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December 2008 Volume 20 Issue 6

Full Size Image

Article

Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer

Authors:
- Isao Ito
- Masaya Mukai
- Hiromi Ninomiya
- Kyoko Kishima
- Kazutoshi Tsuchiya
- Takayuki Tajima
- Masato Nakamura
- Hiroyasu Makuuchi
View Affiliations / Copyright

Affiliations: Tokai University Oiso Hospital, Department of Surgery, Kanagawa 259-0198, Japan. isaoito@is.icc.u-tokai.ac.jp
Pages: 1521-1526
|
Published online on: December 1, 2008

https://doi.org/10.3892/or_00000174
Expand metrics +

Abstract

This study aimed to retrospectively assess the efficacy of postoperative adjuvant chemotherapy in 77 patients who underwent curative resection for stage III colorectal cancer. They were treated by intravenous administration of 5FU + LV (FL-IV group, 38) or oral administration of UFT + PSK (oral group, 39). The 3-year relapse-free (3Y-RFS), 5-year relapse-free (5Y-RFS) and 5-year overall survival (5Y-OS) were calculated for each group, and clinical results and adverse events (AEs) were compared between the two groups. The 3Y-RFS, 5Y-RFS and 5Y-OS were 65.8, 62.7 and 72.3%, respectively, in the FL-IV group and 63.3 (p=0.7957), 56.3 (p=0.7088) and 60.4% (p=0.5293), respectively, in the oral group. These parameters showed no significant differences between the two groups. As AEs, grade 3 leucopenia, nausea/vomiting, and general fatigue were noted in one patient each (2.6%) in the FL-IV group. Grade 3 or more severe AEs were not noted in the oral group. These results suggest that oral immunochemotherapy is one of the options of postoperative adjuvant therapy for stage III colorectal cancer, because it imposes no financial burden on patients and results in high quality of life.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer

This article is mentioned in:

Abstract

Related Articles