Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer

  • Authors:
    • Isao Ito
    • Masaya Mukai
    • Hiromi Ninomiya
    • Kyoko Kishima
    • Kazutoshi Tsuchiya
    • Takayuki Tajima
    • Masato Nakamura
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/or_00000174
  • Pages: 1521-1526
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Abstract

This study aimed to retrospectively assess the efficacy of postoperative adjuvant chemotherapy in 77 patients who underwent curative resection for stage III colorectal cancer. They were treated by intravenous administration of 5FU + LV (FL-IV group, 38) or oral administration of UFT + PSK (oral group, 39). The 3-year relapse-free (3Y-RFS), 5-year relapse-free (5Y-RFS) and 5-year overall survival (5Y-OS) were calculated for each group, and clinical results and adverse events (AEs) were compared between the two groups. The 3Y-RFS, 5Y-RFS and 5Y-OS were 65.8, 62.7 and 72.3%, respectively, in the FL-IV group and 63.3 (p=0.7957), 56.3 (p=0.7088) and 60.4% (p=0.5293), respectively, in the oral group. These parameters showed no significant differences between the two groups. As AEs, grade 3 leucopenia, nausea/vomiting, and general fatigue were noted in one patient each (2.6%) in the FL-IV group. Grade 3 or more severe AEs were not noted in the oral group. These results suggest that oral immunochemotherapy is one of the options of postoperative adjuvant therapy for stage III colorectal cancer, because it imposes no financial burden on patients and results in high quality of life.

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December 2008
Volume 20 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ito I, Mukai M, Ninomiya H, Kishima K, Tsuchiya K, Tajima T, Nakamura M and Makuuchi H: Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer. Oncol Rep 20: 1521-1526, 2008
APA
Ito, I., Mukai, M., Ninomiya, H., Kishima, K., Tsuchiya, K., Tajima, T. ... Makuuchi, H. (2008). Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer. Oncology Reports, 20, 1521-1526. https://doi.org/10.3892/or_00000174
MLA
Ito, I., Mukai, M., Ninomiya, H., Kishima, K., Tsuchiya, K., Tajima, T., Nakamura, M., Makuuchi, H."Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer". Oncology Reports 20.6 (2008): 1521-1526.
Chicago
Ito, I., Mukai, M., Ninomiya, H., Kishima, K., Tsuchiya, K., Tajima, T., Nakamura, M., Makuuchi, H."Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage III colorectal cancer". Oncology Reports 20, no. 6 (2008): 1521-1526. https://doi.org/10.3892/or_00000174