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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2009 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2009 Volume 21 Issue 1

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Article

The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts

  • Authors:
    • Ling Xi
    • Shixuan Wang
    • Changyu Wang
    • Qian Xu
    • Pengcheng Li
    • Xun Tian
    • Peng Wu
    • Wei Wang
    • Dongrui Deng
    • Jianfeng Zhou
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Research Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, P.R. China
  • Pages: 25-31
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/or_00000185
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Abstract

To investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts. HPV-16 E6 and E7 genes were transfected into C33A and HFB to detect the profiling of angiogenesis-associated factors with the TranSignal angiogenesis antibody array. The mRNA and protein levels of the cytokines were examined by traditional RT-PCR and Western blotting in both cell lines before and after transfection of HPV-16 E6 and E7. HPV-16 E6 and E7 genes were successfully transfected into C33A and HFB cells. On the sheet of antibody array, after transfection of HPV-16 E6 and E7, 6 other cytokines, Ang-1, FGFα, HGF, IL-6, IP-10 and PIGF besides VEGF, were detected at higher levels in C33A cells. Expression of 7 other cytokines besides IL-8, Ang-1, IL-1α, IL-1β, HGF, IL-6, VEGF and PIGF increased in HFB cells. The common cytokines in both cell lines were Ang-1, HGF, PIGF and VEGF. The mRNA and protein levels of the four cytokines were verified to increase by traditional RT-PCR and Western blotting in both cell lines after transfection of HPV-16 E6 and E7. Multiple pro-angiogenic cytokines could be stimulated by HPV-16 E6 and E7 protein both in cervical cancer cell line and normal human diploid cells. Anti-angiogenesis therapy may be effective alone or in combination with biologic means aimed at E6 and E7 in the treatment of cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Xi L, Wang S, Wang C, Xu Q, Li P, Tian X, Wu P, Wang W, Deng D, Zhou J, Zhou J, et al: The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts. Oncol Rep 21: 25-31, 2009.
APA
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X. ... Ma, D. (2009). The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts. Oncology Reports, 21, 25-31. https://doi.org/10.3892/or_00000185
MLA
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X., Wu, P., Wang, W., Deng, D., Zhou, J., Ma, D."The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts". Oncology Reports 21.1 (2009): 25-31.
Chicago
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X., Wu, P., Wang, W., Deng, D., Zhou, J., Ma, D."The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts". Oncology Reports 21, no. 1 (2009): 25-31. https://doi.org/10.3892/or_00000185
Copy and paste a formatted citation
x
Spandidos Publications style
Xi L, Wang S, Wang C, Xu Q, Li P, Tian X, Wu P, Wang W, Deng D, Zhou J, Zhou J, et al: The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts. Oncol Rep 21: 25-31, 2009.
APA
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X. ... Ma, D. (2009). The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts. Oncology Reports, 21, 25-31. https://doi.org/10.3892/or_00000185
MLA
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X., Wu, P., Wang, W., Deng, D., Zhou, J., Ma, D."The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts". Oncology Reports 21.1 (2009): 25-31.
Chicago
Xi, L., Wang, S., Wang, C., Xu, Q., Li, P., Tian, X., Wu, P., Wang, W., Deng, D., Zhou, J., Ma, D."The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts". Oncology Reports 21, no. 1 (2009): 25-31. https://doi.org/10.3892/or_00000185
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