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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2009 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death

  • Authors:
    • Yong Hwan Han
    • Woo Hyun Park

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, JeonJu 561-180, Korea
  • Pages: 253-261
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/or_00000216
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Abstract

Antimycin A (AMA) inhibits the mitochondrial electron transport between cytochromes b and c. However, the relationship between AMA and lung cancer cells is poorly understood. In this study, we investigated the involvement of reactive oxygen species (ROS) and glutathione (GSH) in AMA-treated lung cancer Calu-6 cell death. Treatment with AMA reduced cell viability in a dose-dependent manner for 72 h. The intracellular ROS levels were decreased in Calu-6 cells treated with low doses of AMA (10, 25 or 50 µM) at 72 h. However, the levels increased in cells treated with a high dose of 100 µM AMA. Levels of O2·− were significantly increased in AMA-treated cells at 72 h. The increases in ROS levels including O2·− in AMA-treated cells were observed within 10 min. Treatment with AMA reduced the intracellular GSH content. SOD activity was up-regulated in AMA-treated Calu-6 cells at 72 h. However, catalase activity was down-regulated by AMA. Treatment with tiron, a ROS scavenger, reduced the intracellular ROS levels, which were associated with a partial reduction of apoptosis. Treatment with exogenous SOD and catalase significantly inhibited loss of the mitochondrial transmembrane potential (ΔΨm) in AMA-treated Calu-6 cells. In conclusion, our results suggest that the changes of intracellular ROS and GSH affect apoptosis in AMA-treated Calu-6 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Han YH and Park WH: Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncol Rep 21: 253-261, 2009.
APA
Han, Y.H., & Park, W.H. (2009). Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncology Reports, 21, 253-261. https://doi.org/10.3892/or_00000216
MLA
Han, Y. H., Park, W. H."Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death". Oncology Reports 21.1 (2009): 253-261.
Chicago
Han, Y. H., Park, W. H."Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death". Oncology Reports 21, no. 1 (2009): 253-261. https://doi.org/10.3892/or_00000216
Copy and paste a formatted citation
x
Spandidos Publications style
Han YH and Park WH: Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncol Rep 21: 253-261, 2009.
APA
Han, Y.H., & Park, W.H. (2009). Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncology Reports, 21, 253-261. https://doi.org/10.3892/or_00000216
MLA
Han, Y. H., Park, W. H."Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death". Oncology Reports 21.1 (2009): 253-261.
Chicago
Han, Y. H., Park, W. H."Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death". Oncology Reports 21, no. 1 (2009): 253-261. https://doi.org/10.3892/or_00000216
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