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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2009 Volume 21 Issue 4

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Article

Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo

  • Authors:
    • Min Yu
    • Junli Gong
    • Mingxing Ma
    • Hui Yang
    • Jianhua Lai
    • Hong Wu
    • Lin Li
    • Lamei Li
    • Deyong Tan

  • View Affiliations / Copyright

    Affiliations: Laboratory of Biochemistry and Molecular Biology, School of Life Science, Yunnan University, 650091 Kunming, P.R. China
  • Pages: 909-915
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000303
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Abstract

The arrest-defective-1 (ARD1) gene has been reported to be important in yeast cell cycle regulation, and recent studies have shown that human arrest-defective-1 (hARD1) is related to cancer cell proliferation. To investigate the expression pattern of hARD1 protein in cancer tissues, immunohistochemical analysis was performed to analyze the hARD1 expression pattern in 400 cases of 19 types of common cancer and 133 non-cancer samples from 11 tissue types. hARD1 protein was expressed extensively in cancer tissues including glandular carcinoma and squamous cancer, and the positive rate was 71.5% (15/20) in urinary bladder cancer, 62.5% (30/48) in breast cancer and 57.1% (8/14) in cervical carcinoma. The average hARD1-positive rate was 52.3% in cancers and 31.5% in non-cancers, for which the difference was significant (p<0.005). Comparing the staining intensity of different fields in the same section, the hARD1 protein was highly accumulated in cancer cells when compared to the cells adjacent to cancer. The positive rate of breast and intestinal cancer was obviously higher than corresponding non-cancers (p<0.05 and 0.01). These findings suggest that the accumulation of hARD1 protein may be related to carcinogenesis of various types of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yu M, Gong J, Ma M, Yang H, Lai J, Wu H, Li L, Li L and Tan D: Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo. Oncol Rep 21: 909-915, 2009.
APA
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H. ... Tan, D. (2009). Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo. Oncology Reports, 21, 909-915. https://doi.org/10.3892/or_00000303
MLA
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H., Li, L., Li, L., Tan, D."Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo". Oncology Reports 21.4 (2009): 909-915.
Chicago
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H., Li, L., Li, L., Tan, D."Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo". Oncology Reports 21, no. 4 (2009): 909-915. https://doi.org/10.3892/or_00000303
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Gong J, Ma M, Yang H, Lai J, Wu H, Li L, Li L and Tan D: Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo. Oncol Rep 21: 909-915, 2009.
APA
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H. ... Tan, D. (2009). Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo. Oncology Reports, 21, 909-915. https://doi.org/10.3892/or_00000303
MLA
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H., Li, L., Li, L., Tan, D."Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo". Oncology Reports 21.4 (2009): 909-915.
Chicago
Yu, M., Gong, J., Ma, M., Yang, H., Lai, J., Wu, H., Li, L., Li, L., Tan, D."Immunohistochemical analysis of human arrest-defective-1 expressed in cancers in vivo". Oncology Reports 21, no. 4 (2009): 909-915. https://doi.org/10.3892/or_00000303
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