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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA

  • Authors:
    • Xudong Liu
    • Qihuan Xu
    • Wei Chen
    • Hong Cao
    • Rongjiong Zheng
    • Gang Li

  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, P.R. China
  • Pages: 941-947
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000307
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Abstract

Hepatitis B virus has been linked to the pathogenesis and carcinogenesis of hepatocellular carcinoma. Components of viruses have been identified within pathological specimens of hepatocellular carcinoma tissue. We characterized the in vitro response of human normal liver cells (L-02 cells) to components of infectious agents related to toll-like receptors. Immortalized human normal liver cells (L-02 cells) exhibited increased proliferation in response to exposure to CpG DNA. This molecule is a well-characterized surrogate for DNA viruses, which are common in the liver. Our experiments show that L-02 cells and some hepatoma cell lines such as HepG2, HuH7, Hep3B, express TLR 9 (CpG-specific). CpG DNA, HBV DNA, DNA of HBV middle envelope protein (MP) containing a number of CpG, supernatant of HepG2.2.15 (HepG2 cells transfected HBV) excreting HBV DNA and extraction of nucleic acids from HepG2.2.15 supernatant can all activate NF-κB. In addition, L-02 cells were less susceptible to TNF-α-induced apoptosis as measured by Annexin V-FITC staining when stimulated with CpG. mRNA of DNA methyltransferase 1 (DNMT-1) and BCL-2 was increased when L-02 cells were stimulated with CpG DNA. Our study has identified a possible novel mechanism that indicates how CpG DNA of HBV DNA may contribute to the malignant transformation of benign liver cells.

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Xu Q, Chen W, Cao H, Zheng R and Li G: Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA. Oncol Rep 21: 941-947, 2009.
APA
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., & Li, G. (2009). Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA. Oncology Reports, 21, 941-947. https://doi.org/10.3892/or_00000307
MLA
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., Li, G."Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA". Oncology Reports 21.4 (2009): 941-947.
Chicago
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., Li, G."Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA". Oncology Reports 21, no. 4 (2009): 941-947. https://doi.org/10.3892/or_00000307
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Xu Q, Chen W, Cao H, Zheng R and Li G: Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA. Oncol Rep 21: 941-947, 2009.
APA
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., & Li, G. (2009). Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA. Oncology Reports, 21, 941-947. https://doi.org/10.3892/or_00000307
MLA
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., Li, G."Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA". Oncology Reports 21.4 (2009): 941-947.
Chicago
Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R., Li, G."Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA". Oncology Reports 21, no. 4 (2009): 941-947. https://doi.org/10.3892/or_00000307
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