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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin

  • Authors:
    • Jianli Yang
    • Ji Wang
    • Jia Zhao
    • Dan Zuo
    • Xingrong Li
    • Li Wang

  • View Affiliations / Copyright

    Affiliations: Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun, P.R. China
  • Pages: 949-955
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000308
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Abstract

Basic fibroblast growth factor (bFGF) is closely involved in angiogenesis and tumor growth of various cancers, but its role in cervical cancer remains to be defined. We investigated the effects of bFGF on HeLa cell growth and studied its influence on the expression of angiogenin. We transfected the bFGF gene in the sense and antisense orientation into HeLa cells, and obtained stable bFGF underexpressing and overexpressing transfectants. In our experiments, we demonstrated that inhibition of bFGF gene and protein expression in the bFGF antisense transfectants induced increased protein expression of angiogenin. In contrast, in the bFGF sense transfectants the expression of angiogenin decreased. Delivery of recombinant angiogenin into transfected and control cells led to increased proliferation in the bFGF antisense transfectants and the control cells. However, the cell proliferation had no change in the bFGF sense transfectants. In conclusion, we demonstrated that besides its angiogenic activity, bFGF and angiogenin also directly contribute to HeLa cell proliferation. Furthermore, endogenous bFGF affects the expression of angiogenin in HeLa cells. These findings suggest that inhibition of bFGF alone is not a promising strategy to inhibit angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Wang J, Zhao J, Zuo D, Li X and Wang L: Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. Oncol Rep 21: 949-955, 2009.
APA
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., & Wang, L. (2009). Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. Oncology Reports, 21, 949-955. https://doi.org/10.3892/or_00000308
MLA
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., Wang, L."Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin". Oncology Reports 21.4 (2009): 949-955.
Chicago
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., Wang, L."Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin". Oncology Reports 21, no. 4 (2009): 949-955. https://doi.org/10.3892/or_00000308
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Wang J, Zhao J, Zuo D, Li X and Wang L: Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. Oncol Rep 21: 949-955, 2009.
APA
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., & Wang, L. (2009). Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. Oncology Reports, 21, 949-955. https://doi.org/10.3892/or_00000308
MLA
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., Wang, L."Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin". Oncology Reports 21.4 (2009): 949-955.
Chicago
Yang, J., Wang, J., Zhao, J., Zuo, D., Li, X., Wang, L."Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin". Oncology Reports 21, no. 4 (2009): 949-955. https://doi.org/10.3892/or_00000308
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