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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses

  • Authors:
    • Xiangjiao Meng
    • Xiuwen Wang
    • Yawei Wang

  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Oncology Center, Qilu Hospital, Shandong University, Jinan 250012, P.R. China
  • Pages: 995-1000
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000314
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Abstract

Cancer stem cells have been isolated from human lung cancer and cancer cell lines. This study was designed to investigate the fraction of cancer stem cells in the A549 and H446 cell lines by cloning and tumorigenic analyses. We found that >45% of A549 and H446 cells formed large clones that are able to generate subclones and subsequently give rise to xenograft tumors in the BALB/C-nude mouse. Both CD133+ and CD133− cells of A549 and H446 possessed stem cell characteristics and exposure to Hoechst 33342 affected the clonogenicity and proliferation of single A549 and H446 cell. Moreover, based on cell cycle phase distribution and growth curve, most A549 and H446 cells may not be stem cells, but they acquired stem cell characteristics when they were alone. Therefore, these cells that formed large clones should be called cancer initiating cells, not stem cells. Thus, we concluded that >45% of A549 and H446 cells were cancer initiating cells, although many of them were neither CD133+ cells nor side population cells.

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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Wang X and Wang Y: More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses. Oncol Rep 21: 995-1000, 2009.
APA
Meng, X., Wang, X., & Wang, Y. (2009). More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses. Oncology Reports, 21, 995-1000. https://doi.org/10.3892/or_00000314
MLA
Meng, X., Wang, X., Wang, Y."More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses". Oncology Reports 21.4 (2009): 995-1000.
Chicago
Meng, X., Wang, X., Wang, Y."More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses". Oncology Reports 21, no. 4 (2009): 995-1000. https://doi.org/10.3892/or_00000314
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Wang X and Wang Y: More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses. Oncol Rep 21: 995-1000, 2009.
APA
Meng, X., Wang, X., & Wang, Y. (2009). More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses. Oncology Reports, 21, 995-1000. https://doi.org/10.3892/or_00000314
MLA
Meng, X., Wang, X., Wang, Y."More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses". Oncology Reports 21.4 (2009): 995-1000.
Chicago
Meng, X., Wang, X., Wang, Y."More than 45% of A549 and H446 cells are cancer initiating cells: Evidence from cloning and tumorigenic analyses". Oncology Reports 21, no. 4 (2009): 995-1000. https://doi.org/10.3892/or_00000314
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