Seventeen years of experience with ATRA-based therapy for acute promyelocytic leukaemia: Long-term follow-up of patients treated at S. Martino Hospital, Genoa

Clavio,Marino; Ghiso,Anna; Ghiggi,Chiara; Spriano,Mauro; Colombo,Nicoletta; Grasso,Raffaella; Varaldo,Riccardo; Miglino,Maurizio; Pierri,Ivana; Olcese,Francesca; Aquino,Sara; Biasco,Samantha; Balleari,Enrico; Carella,Angelo Michele; Sessarego,Mario; Gobbi,Marco

doi:10.3892/or_00000322

April 2009 Volume 21 Issue 4

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April 2009 Volume 21 Issue 4

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Article

Seventeen years of experience with ATRA-based therapy for acute promyelocytic leukaemia: Long-term follow-up of patients treated at S. Martino Hospital, Genoa

Authors:
- Marino Clavio
- Anna Ghiso
- Chiara Ghiggi
- Mauro Spriano
- Nicoletta Colombo
- Raffaella Grasso
- Riccardo Varaldo
- Maurizio Miglino
- Ivana Pierri
- Francesca Olcese
- Sara Aquino
- Samantha Biasco
- Enrico Balleari
- Angelo Michele Carella
- Mario Sessarego
- Marco Gobbi
View Affiliations / Copyright

Affiliations: Department of Haematology, University of Genoa, 16132 Genoa, Italy. claviom@unige.it
Pages: 1045-1052
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Published online on: April 1, 2009

https://doi.org/10.3892/or_00000322
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Abstract

We conducted a long-term follow-up retrospective study on 91 consecutive newly diagnosed acute promyelocytic leukaemia (APL) patients. Induction and consolidation therapy were well-tolerated by most patients. Of the 79 patients who were initially treated with the all-trans retinoic acid (ATRA)-containing regimens, there were 3 haemorrhagic deaths during the first period of therapy (4%) and one in consolidation which was due to infection. Following consolidation, molecular assessment of response was performed on 67 patients, and 66 were found to have achieved cytogenetic and molecular remission (98%). After a median follow-up of 100 months (12-192), 10 of the 75 patients who achieved complete remission (13%) relapsed. Seventy-eight percent of the patients were expected to be alive at 14 years from diagnosis, i.e., 90 and 48% of patients of intermediate-low risk and high risk at presentation, respectively (p=0.0009). Sixty-nine patients were in molecular remission after first-line and/or salvage therapy (74%). To date, 4 patients out of the 91 have undergone salvage allogeneic transplant (4%).

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Seventeen years of experience with ATRA-based therapy for acute promyelocytic leukaemia: Long-term follow-up of patients treated at S. Martino Hospital, Genoa

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