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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2009 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 22 Issue 1

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Article

Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

  • Authors:
    • Joo Heon Kim
    • Chang Nam Kim
    • Soo Young Kim
    • Jung Sam Lee
    • Daeho Cho
    • Jae Wha Kim
    • Sun Young Yoon

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Eulji University School of Medicine, Daejeon 301-070, Korea
  • Pages: 41-47
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/or_00000404
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Abstract

To investigate the expression levels of S100A4 in human colorectal carcinoma (CC) and its relationship with clinicopathological parameters and metastatic potential, 73 pathological specimens from patients with CC were examined for S100A4 expression by RT-PCR and immunohistochemistry. An increase of S100A4 mRNA was observed in 19/23 (82.6%) CC specimens, and S100A4 was up-regulated in 40/73 (54.7%) CC cases compared with non-neoplastic mucosal tissues. Upregulation of S100A4 was significantly related to invasion, nodal status, distant metastasis and p53 expression. Next, we investigated whether S100A4 could affect p53 transactivation and stability. Interestingly, it was revealed that treatment with exogenous S100A4 protein reduced transcriptional activity of p53 and abrogated the modification of calcium binding affinity of S100A4 protein. These findings suggested that S100A4 might be involved in the progression and metastasis of human CC, presumably via modulation of the wild-type p53 protein.

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Copy and paste a formatted citation
Spandidos Publications style
Kim JH, Kim CN, Kim SY, Lee JS, Cho D, Kim JW and Yoon SY: Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncol Rep 22: 41-47, 2009.
APA
Kim, J.H., Kim, C.N., Kim, S.Y., Lee, J.S., Cho, D., Kim, J.W., & Yoon, S.Y. (2009). Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncology Reports, 22, 41-47. https://doi.org/10.3892/or_00000404
MLA
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22.1 (2009): 41-47.
Chicago
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22, no. 1 (2009): 41-47. https://doi.org/10.3892/or_00000404
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JH, Kim CN, Kim SY, Lee JS, Cho D, Kim JW and Yoon SY: Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncol Rep 22: 41-47, 2009.
APA
Kim, J.H., Kim, C.N., Kim, S.Y., Lee, J.S., Cho, D., Kim, J.W., & Yoon, S.Y. (2009). Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncology Reports, 22, 41-47. https://doi.org/10.3892/or_00000404
MLA
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22.1 (2009): 41-47.
Chicago
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22, no. 1 (2009): 41-47. https://doi.org/10.3892/or_00000404
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