Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

  • Authors:
    • Joo Heon Kim
    • Chang Nam Kim
    • Soo Young Kim
    • Jung Sam Lee
    • Daeho Cho
    • Jae Wha Kim
    • Sun Young Yoon
  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/or_00000404
  • Pages: 41-47
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Abstract

To investigate the expression levels of S100A4 in human colorectal carcinoma (CC) and its relationship with clinicopathological parameters and metastatic potential, 73 pathological specimens from patients with CC were examined for S100A4 expression by RT-PCR and immunohistochemistry. An increase of S100A4 mRNA was observed in 19/23 (82.6%) CC specimens, and S100A4 was up-regulated in 40/73 (54.7%) CC cases compared with non-neoplastic mucosal tissues. Upregulation of S100A4 was significantly related to invasion, nodal status, distant metastasis and p53 expression. Next, we investigated whether S100A4 could affect p53 transactivation and stability. Interestingly, it was revealed that treatment with exogenous S100A4 protein reduced transcriptional activity of p53 and abrogated the modification of calcium binding affinity of S100A4 protein. These findings suggested that S100A4 might be involved in the progression and metastasis of human CC, presumably via modulation of the wild-type p53 protein.

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July 2009
Volume 22 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim JH, Kim CN, Kim SY, Lee JS, Cho D, Kim JW and Yoon SY: Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncol Rep 22: 41-47, 2009
APA
Kim, J.H., Kim, C.N., Kim, S.Y., Lee, J.S., Cho, D., Kim, J.W., & Yoon, S.Y. (2009). Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer. Oncology Reports, 22, 41-47. https://doi.org/10.3892/or_00000404
MLA
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22.1 (2009): 41-47.
Chicago
Kim, J. H., Kim, C. N., Kim, S. Y., Lee, J. S., Cho, D., Kim, J. W., Yoon, S. Y."Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer". Oncology Reports 22, no. 1 (2009): 41-47. https://doi.org/10.3892/or_00000404