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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2009 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2009 Volume 22 Issue 2

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Article

The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line

  • Authors:
    • Shu-Xia Liu
    • Yu-Jun Zhang
    • Hui-Fang Guo
    • Jun Hao
    • Qing-Juan Liu
    • Jun-Ru Liu
    • Jian-Wen Guo
    • Jiang-Hui Liu
    • Lian-Fu Zuo

  • View Affiliations / Copyright

    Affiliations: Department of pathology, Hebei Medical University, Shijiazhuang 050017, P.R. China
  • Pages: 313-319
    |
    Published online on: August 1, 2009
       https://doi.org/10.3892/or_00000439
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Abstract

Valdecoxib is a second generation selective COX-2 inhibitor that can induce cell apoptosis in a variety of cell types, but its precise regulatory mechanism is unknown. Apoptosis of Eca109 cells and p38 mRNA expression were investigted. The expression of p-p38MAPK, Fas and FasL proteins were detected by immunohistochemical staining and FCM. Valdecoxib increased the apoptosis rate of Eca109 cells. Fas and FasL protein expression was up-regulated in the valdecoxib groups, while SB203580 partly inhibited the valdecoxib-induced overexpression. Valdecoxib increased p38MAPK expression, while SB203580 inhibited the overexpression of this protein and the apoptosis rate decreased. The expression of Fas, FasL and p38MAPK protein were positively correlated with the apoptotic rate. In conclusion, valdecoxib activates the p38MAPK pathway, thus up-regulating expression of the Fas and FasL proteins, which may be one of the mechanisms through which valdecoxib induces apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Liu S, Zhang Y, Guo H, Hao J, Liu Q, Liu J, Guo J, Liu J and Zuo L: The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. Oncol Rep 22: 313-319, 2009.
APA
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J. ... Zuo, L. (2009). The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. Oncology Reports, 22, 313-319. https://doi.org/10.3892/or_00000439
MLA
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J., Guo, J., Liu, J., Zuo, L."The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line". Oncology Reports 22.2 (2009): 313-319.
Chicago
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J., Guo, J., Liu, J., Zuo, L."The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line". Oncology Reports 22, no. 2 (2009): 313-319. https://doi.org/10.3892/or_00000439
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Zhang Y, Guo H, Hao J, Liu Q, Liu J, Guo J, Liu J and Zuo L: The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. Oncol Rep 22: 313-319, 2009.
APA
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J. ... Zuo, L. (2009). The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. Oncology Reports, 22, 313-319. https://doi.org/10.3892/or_00000439
MLA
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J., Guo, J., Liu, J., Zuo, L."The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line". Oncology Reports 22.2 (2009): 313-319.
Chicago
Liu, S., Zhang, Y., Guo, H., Hao, J., Liu, Q., Liu, J., Guo, J., Liu, J., Zuo, L."The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line". Oncology Reports 22, no. 2 (2009): 313-319. https://doi.org/10.3892/or_00000439
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