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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2009 Volume 22 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 22 Issue 3

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Review

Peroxisome proliferator-activated receptor δ and gastric cancer (Review)

  • Authors:
    • Chung W. Wu
    • Jun Yu
    • Joseph J.Y. Sung

  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Therapeutics, Prince of Wales Hospital, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, P.R. China
  • Pages: 451-457
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/or_00000456
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Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily which form heterodimers with retinoid X receptors (RXRs) in nucleus and bind to the PPAR response elements (PPREs) of target genes, leading to a wide spectrum of physiological functions. With an improved understanding of its physiological role, PPARδ and its agonist have been gaining attention in cancer research in recent years. Despite the paucity of research concerning the direct relationship between PPARδ and gastric cancer, there is substantial evidence that PPARδ may play a role in the development of gastric cancer. This review focuses on recent literature describing the role of PPARδ, especially in its association with nuclear factor-κB (NF-κB), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2) and Wnt-β-catenin/TCF-4 pathways on gastric tumorigenesis and highlights critical discrepancies that need to be resolved for a more comprehensive understanding of how this receptor modulates gastric tumorigenesis. The potential role of PPARδ as a therapeutic target in the treatment of gastric cancer deserves further research focus.

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Copy and paste a formatted citation
Spandidos Publications style
Wu CW, Yu J and Sung JJ: Peroxisome proliferator-activated receptor δ and gastric cancer (Review). Oncol Rep 22: 451-457, 2009.
APA
Wu, C.W., Yu, J., & Sung, J.J. (2009). Peroxisome proliferator-activated receptor δ and gastric cancer (Review). Oncology Reports, 22, 451-457. https://doi.org/10.3892/or_00000456
MLA
Wu, C. W., Yu, J., Sung, J. J."Peroxisome proliferator-activated receptor δ and gastric cancer (Review)". Oncology Reports 22.3 (2009): 451-457.
Chicago
Wu, C. W., Yu, J., Sung, J. J."Peroxisome proliferator-activated receptor δ and gastric cancer (Review)". Oncology Reports 22, no. 3 (2009): 451-457. https://doi.org/10.3892/or_00000456
Copy and paste a formatted citation
x
Spandidos Publications style
Wu CW, Yu J and Sung JJ: Peroxisome proliferator-activated receptor δ and gastric cancer (Review). Oncol Rep 22: 451-457, 2009.
APA
Wu, C.W., Yu, J., & Sung, J.J. (2009). Peroxisome proliferator-activated receptor δ and gastric cancer (Review). Oncology Reports, 22, 451-457. https://doi.org/10.3892/or_00000456
MLA
Wu, C. W., Yu, J., Sung, J. J."Peroxisome proliferator-activated receptor δ and gastric cancer (Review)". Oncology Reports 22.3 (2009): 451-457.
Chicago
Wu, C. W., Yu, J., Sung, J. J."Peroxisome proliferator-activated receptor δ and gastric cancer (Review)". Oncology Reports 22, no. 3 (2009): 451-457. https://doi.org/10.3892/or_00000456
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