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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2009 Volume 22 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 22 Issue 3

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Article

Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells

  • Authors:
    • Xian-Ling Guo
    • Nan-Nan Ma
    • Fei-Guo Zhou
    • Li Zhang
    • Xin-Xin Bu
    • Kai Sun
    • Jian-Rui Song
    • Rong Li
    • Bai-He Zhang
    • Meng-Chao Wu
    • Li-Xin Wei

  • View Affiliations / Copyright

    Affiliations: Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, P.R. China
  • Pages: 549-556
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/or_00000470
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Abstract

The telomerase is specifically activated in most malignant tumors but is usually inactive in normal somatic cells. It has been reported that telomerase has an anti-apoptotic role and up-regulation of telomerase helps cancer cells to be resistant to chemotherapeutic agent-induced cell death. The effect of cisplatin on telomerase activity is complex, and the exact mechanism remains largely unknown. In this study, we found that cisplatin activated telomerase activity and human telomerase reverse transcriptase (hTERT) expression in SMMC7721 human hepatocellular carcinoma cell line. Low-dose cisplatin up-regulated hTERT and NF-κB p65 expression and increased telomerase and NF-κB activity. Inhibition of NF-κB attenuated the hTERT expression and telomerase activity exposed to cisplatin, suggesting that NF-κB is responsible for the cisplatin-induced activation of the hTERT. Furthermore, preincubation of low-dose cisplatin which induced high expression of hTERT help hepatocellular carcinoma SMMC7721 cells survive under the high concentration of anti-cancer drugs. Inhibition of hTERT increased sensitivity of SMMC7721 cells to chemotherapy. Taken together, these results suggested that up-regulation of hTERT expression by low-dose cisplatin is NF-κB-dependent and contributes to chemotherapy resistance in human hepatocellular cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Ma N, Zhou F, Zhang L, Bu X, Sun K, Song J, Li R, Zhang B, Wu M, Wu M, et al: Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells. Oncol Rep 22: 549-556, 2009.
APA
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K. ... Wei, L. (2009). Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells. Oncology Reports, 22, 549-556. https://doi.org/10.3892/or_00000470
MLA
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K., Song, J., Li, R., Zhang, B., Wu, M., Wei, L."Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells". Oncology Reports 22.3 (2009): 549-556.
Chicago
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K., Song, J., Li, R., Zhang, B., Wu, M., Wei, L."Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells". Oncology Reports 22, no. 3 (2009): 549-556. https://doi.org/10.3892/or_00000470
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Ma N, Zhou F, Zhang L, Bu X, Sun K, Song J, Li R, Zhang B, Wu M, Wu M, et al: Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells. Oncol Rep 22: 549-556, 2009.
APA
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K. ... Wei, L. (2009). Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells. Oncology Reports, 22, 549-556. https://doi.org/10.3892/or_00000470
MLA
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K., Song, J., Li, R., Zhang, B., Wu, M., Wei, L."Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells". Oncology Reports 22.3 (2009): 549-556.
Chicago
Guo, X., Ma, N., Zhou, F., Zhang, L., Bu, X., Sun, K., Song, J., Li, R., Zhang, B., Wu, M., Wei, L."Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells". Oncology Reports 22, no. 3 (2009): 549-556. https://doi.org/10.3892/or_00000470
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