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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2009 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2009 Volume 22 Issue 4

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Article

Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects

  • Authors:
    • Jinbao Zong
    • Qinglin Peng
    • Qingyong Wang
    • Ting Zhang
    • Dongsheng Fan
    • Xuemei Xu

  • View Affiliations / Copyright

    Affiliations: Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, P.R. China
  • Pages: 953-961
    |
    Published online on: October 1, 2009
       https://doi.org/10.3892/or_00000522
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Abstract

Cervical cancer is one of the most common cancers in women worldwide and persistent infection with human papilloma virus (HPV)s is considered to be the major risk factor. Millions of women are currently infected with high risk genotypes. Therefore, it is imperative to develop therapeutic vaccines to eliminate established infection or HPV-related disease. In the current study, we generated two potential therapeutic HPV DNA vaccines, SigmE7/MtHSP70 and SigmE7/HuHSP70, using human and mycobacterium tuberculosis HSP70 linked, respectively, to HPV16 mE7 and the signal peptide gene of human CD33. Our comparative evaluation of these two vaccines found that vaccination with the SigmE7/HuHSP70 DNA vaccine induced a stronger E7-specific CD8+ T cell immune response and resulted in a more significant therapeutic effect against E7 expressing tumor cells. Our study may serve as an important foundation and significant reference for future clinical applications.

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Copy and paste a formatted citation
Spandidos Publications style
Zong J, Peng Q, Wang Q, Zhang T, Fan D and Xu X: Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects. Oncol Rep 22: 953-961, 2009.
APA
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., & Xu, X. (2009). Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects. Oncology Reports, 22, 953-961. https://doi.org/10.3892/or_00000522
MLA
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., Xu, X."Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects". Oncology Reports 22.4 (2009): 953-961.
Chicago
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., Xu, X."Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects". Oncology Reports 22, no. 4 (2009): 953-961. https://doi.org/10.3892/or_00000522
Copy and paste a formatted citation
x
Spandidos Publications style
Zong J, Peng Q, Wang Q, Zhang T, Fan D and Xu X: Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects. Oncol Rep 22: 953-961, 2009.
APA
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., & Xu, X. (2009). Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects. Oncology Reports, 22, 953-961. https://doi.org/10.3892/or_00000522
MLA
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., Xu, X."Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects". Oncology Reports 22.4 (2009): 953-961.
Chicago
Zong, J., Peng, Q., Wang, Q., Zhang, T., Fan, D., Xu, X."Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects". Oncology Reports 22, no. 4 (2009): 953-961. https://doi.org/10.3892/or_00000522
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