Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase

  • Authors:
    • Ping Cheng
    • Yuhua Li
    • Liping Yang
    • Yanjun Wen
    • Wei Shi
    • Yongqiu Mao
    • Ping Chen
    • Huimin Lv
    • Qingqing Tang
    • Yuquan Wei
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/or_00000542
  • Pages: 1101-1107
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Abstract

Hepatitis B virus X protein (HBx) is a multi-functional regulatory protein that is known to be involved in viral proliferation, transcriptional activation and cell growth control. However, the actual role of HBx in cell growth control remains controversial. In this study, the impact of HBx on cell growth in vitro and in vivo was further investigated. HBx was able to inhibit the growth of hepatocellular carcinoma (HCC) cells and induce G2/M arrest in vitro. Moreover, unlike many other G2/M arrest mechanisms, HBx did not inhibit cyclin B1-CDK1 kinase activity, but it persistently activated the cyclin B1-CDK1 kinase. In vivo, HBx inhibited tumor cell growth and induced apoptosis as well as inhibited the growth of vascular endothelial cells. In conclusion, HBx induced G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase, and negatively regulated cell growth in vitro and in vivo.

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November 2009
Volume 22 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cheng P, Li Y, Yang L, Wen Y, Shi W, Mao Y, Chen P, Lv H, Tang Q, Wei Y, Wei Y, et al: Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncol Rep 22: 1101-1107, 2009
APA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y. ... Wei, Y. (2009). Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncology Reports, 22, 1101-1107. https://doi.org/10.3892/or_00000542
MLA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22.5 (2009): 1101-1107.
Chicago
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22, no. 5 (2009): 1101-1107. https://doi.org/10.3892/or_00000542