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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 22 Issue 5

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Article

Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase

  • Authors:
    • Ping Cheng
    • Yuhua Li
    • Liping Yang
    • Yanjun Wen
    • Wei Shi
    • Yongqiu Mao
    • Ping Chen
    • Huimin Lv
    • Qingqing Tang
    • Yuquan Wei

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy, West China Hospital, Sichuan 610041, P.R. China
  • Pages: 1101-1107
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000542
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Abstract

Hepatitis B virus X protein (HBx) is a multi-functional regulatory protein that is known to be involved in viral proliferation, transcriptional activation and cell growth control. However, the actual role of HBx in cell growth control remains controversial. In this study, the impact of HBx on cell growth in vitro and in vivo was further investigated. HBx was able to inhibit the growth of hepatocellular carcinoma (HCC) cells and induce G2/M arrest in vitro. Moreover, unlike many other G2/M arrest mechanisms, HBx did not inhibit cyclin B1-CDK1 kinase activity, but it persistently activated the cyclin B1-CDK1 kinase. In vivo, HBx inhibited tumor cell growth and induced apoptosis as well as inhibited the growth of vascular endothelial cells. In conclusion, HBx induced G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase, and negatively regulated cell growth in vitro and in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Cheng P, Li Y, Yang L, Wen Y, Shi W, Mao Y, Chen P, Lv H, Tang Q, Wei Y, Wei Y, et al: Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncol Rep 22: 1101-1107, 2009.
APA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y. ... Wei, Y. (2009). Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncology Reports, 22, 1101-1107. https://doi.org/10.3892/or_00000542
MLA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22.5 (2009): 1101-1107.
Chicago
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22, no. 5 (2009): 1101-1107. https://doi.org/10.3892/or_00000542
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng P, Li Y, Yang L, Wen Y, Shi W, Mao Y, Chen P, Lv H, Tang Q, Wei Y, Wei Y, et al: Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncol Rep 22: 1101-1107, 2009.
APA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y. ... Wei, Y. (2009). Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Oncology Reports, 22, 1101-1107. https://doi.org/10.3892/or_00000542
MLA
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22.5 (2009): 1101-1107.
Chicago
Cheng, P., Li, Y., Yang, L., Wen, Y., Shi, W., Mao, Y., Chen, P., Lv, H., Tang, Q., Wei, Y."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase". Oncology Reports 22, no. 5 (2009): 1101-1107. https://doi.org/10.3892/or_00000542
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