Expression and prognostic value of L1-CAM in breast cancer

  • Authors:
    • Christine Schröder
    • Udo Schumacher
    • Mina Fogel
    • Friedrich Feuerhake
    • Volkmar Müller
    • Ralph M. Wirtz
    • Peter Altevogt
    • Sylke Krenkel
    • Fritz Jänicke
    • Karin Milde-Langosch
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/or_00000543
  • Pages: 1109-1117
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Abstract

The L1 adhesion molecule (L1-CAM) is associated with impaired prognosis in many carcinomas. However, limited information about its expression in breast cancer tissue is available. Therefore, we carried out an analysis on L1 expression in primary breast cancers using a combination of Western blot, DNA-microarray analysis and immunohistochemistry. We observed L1 protein and mRNA overexpression in 14-15% of the carcinomas and this was confirmed by immunohistochemical staining. High L1 expression was associated with nodal involvement, high grading, human epidermal growth receptor 2 (Her-2), plasminogen activator inhibitor 1 (PAI-1) and vascular endothelial growth factor (VEGF) expression and a negative estrogen receptor (ER) status, but not with neuroendocrine markers. Moreover, patients with tumors showing high L1-CAM expression had a shorter disease-free and overall survival. Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well.

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November 2009
Volume 22 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Schröder C, Schumacher U, Fogel M, Feuerhake F, Müller V, Wirtz RM, Altevogt P, Krenkel S, Jänicke F, Milde-Langosch K, Milde-Langosch K, et al: Expression and prognostic value of L1-CAM in breast cancer. Oncol Rep 22: 1109-1117, 2009.
APA
Schröder, C., Schumacher, U., Fogel, M., Feuerhake, F., Müller, V., Wirtz, R.M. ... Milde-Langosch, K. (2009). Expression and prognostic value of L1-CAM in breast cancer. Oncology Reports, 22, 1109-1117. https://doi.org/10.3892/or_00000543
MLA
Schröder, C., Schumacher, U., Fogel, M., Feuerhake, F., Müller, V., Wirtz, R. M., Altevogt, P., Krenkel, S., Jänicke, F., Milde-Langosch, K."Expression and prognostic value of L1-CAM in breast cancer". Oncology Reports 22.5 (2009): 1109-1117.
Chicago
Schröder, C., Schumacher, U., Fogel, M., Feuerhake, F., Müller, V., Wirtz, R. M., Altevogt, P., Krenkel, S., Jänicke, F., Milde-Langosch, K."Expression and prognostic value of L1-CAM in breast cancer". Oncology Reports 22, no. 5 (2009): 1109-1117. https://doi.org/10.3892/or_00000543