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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 22 Issue 5

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Article

Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer

  • Authors:
    • Roman Hrstka
    • Michal Beranek
    • Katerina Klocova
    • Rudolf Nenutil
    • Borivoj Vojtesek

  • View Affiliations / Copyright

    Affiliations: Department of Oncological and Experimental Pathology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic
  • Pages: 1205-1211
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000556
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Abstract

Recent studies have suggested that genetic polymorphisms in the TP53 pathway influence tumour formation, progression and response to therapy. We analysed the three most common TP53 gene polymorphisms as potential genetic markers to predict the development and prognosis of breast cancer. The incidence of R72P, PIN3 Ins 16bp and PIN6 G13494A polymorphisms was determined in a cohort of 117 breast cancer tissues and 108 control specimens by PCR-RFLP. No significant difference was observed in the polymorphism variants in breast cancer specimens compared to controls. Furthermore, no statistically significant association of these polymorphisms with the outcome of the patients was observed. On the other hand we found positive correlation of lymph node metastases with both PIN3 Ins 16bp and PIN6 G13494A polymorphisms. The association of intronic TP53 variants with an aggressive breast cancer phenotype may represent a useful predictive biomarker, particularly in patients of clinical stage I with low or intermediate risk.

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Copy and paste a formatted citation
Spandidos Publications style
Hrstka R, Beranek M, Klocova K, Nenutil R and Vojtesek B: Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer. Oncol Rep 22: 1205-1211, 2009.
APA
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., & Vojtesek, B. (2009). Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer. Oncology Reports, 22, 1205-1211. https://doi.org/10.3892/or_00000556
MLA
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., Vojtesek, B."Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer". Oncology Reports 22.5 (2009): 1205-1211.
Chicago
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., Vojtesek, B."Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer". Oncology Reports 22, no. 5 (2009): 1205-1211. https://doi.org/10.3892/or_00000556
Copy and paste a formatted citation
x
Spandidos Publications style
Hrstka R, Beranek M, Klocova K, Nenutil R and Vojtesek B: Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer. Oncol Rep 22: 1205-1211, 2009.
APA
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., & Vojtesek, B. (2009). Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer. Oncology Reports, 22, 1205-1211. https://doi.org/10.3892/or_00000556
MLA
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., Vojtesek, B."Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer". Oncology Reports 22.5 (2009): 1205-1211.
Chicago
Hrstka, R., Beranek, M., Klocova, K., Nenutil, R., Vojtesek, B."Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer". Oncology Reports 22, no. 5 (2009): 1205-1211. https://doi.org/10.3892/or_00000556
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