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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 22 Issue 5

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Article

A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation

  • Authors:
    • Yajuan Li
    • Shuang Liu
    • Fengmin Lu
    • Ting Zhang
    • Hairu Chen
    • Songwei Wu
    • Hui Zhuang

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Peking University Health Science Center, Beijing 100191, P.R. China
  • Pages: 1229-1235
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000559
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Abstract

The role of T-type Ca2+ channels in hepatocellular carcinoma cell proliferation was investigated in vitro. Eleven hepatocellular carcinoma cell lines and one immortalized liver cell line (LO2) were examined for the status of T-type Ca2+ channels with RT-PCR and voltage-clamp recordings. Except HBxF344, other cell lines tested had one, two or all three of α1-subunits (α1G, α1H and α1I) mRNA expression. Obvious T-type current was recorded in SNU449 cells, while others exhibited a minimal or no T-type current. SNU449, PLC/PRF5, Hep3B and LO2 cell lines were subjected to growth assay in the presence of Mibefradil, a T-type Ca2+ channel blocker, only the proliferation of SNU449 cell which had functional T-type Ca2+ channel was reduced by Mibefradil treatment. Furthermore, the persistent increase of phosphorylated ERK1/2 in SNU449 cells was found when treated with Mibefradil. A microarray assay also demonstrated some down-regulated genes were mainly associated with cell cycle and cell proliferation in Mibefradil treated SNU449 cells. In conclusion, this study showed that the functional T-type Ca2+ channels probably participate in modulating the proliferation of some hepatocellular carcinoma cells. The cell proliferation reduction of SNU449 with Mibefradil treatment is possibly associated with the persistent increase of phosphorylated ERK1/2.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu S, Lu F, Zhang T, Chen H, Wu S and Zhuang H: A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation. Oncol Rep 22: 1229-1235, 2009.
APA
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., & Zhuang, H. (2009). A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation. Oncology Reports, 22, 1229-1235. https://doi.org/10.3892/or_00000559
MLA
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., Zhuang, H."A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation". Oncology Reports 22.5 (2009): 1229-1235.
Chicago
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., Zhuang, H."A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation". Oncology Reports 22, no. 5 (2009): 1229-1235. https://doi.org/10.3892/or_00000559
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu S, Lu F, Zhang T, Chen H, Wu S and Zhuang H: A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation. Oncol Rep 22: 1229-1235, 2009.
APA
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., & Zhuang, H. (2009). A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation. Oncology Reports, 22, 1229-1235. https://doi.org/10.3892/or_00000559
MLA
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., Zhuang, H."A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation". Oncology Reports 22.5 (2009): 1229-1235.
Chicago
Li, Y., Liu, S., Lu, F., Zhang, T., Chen, H., Wu, S., Zhuang, H."A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation". Oncology Reports 22, no. 5 (2009): 1229-1235. https://doi.org/10.3892/or_00000559
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