Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism

  • Authors:
    • Wenbo Zhu
    • Haiyan Hu
    • Pengxin Qiu
    • Guangmei Yan
  • View Affiliations

  • Published online on: December 1, 2009     https://doi.org/10.3892/or_00000580
  • Pages: 1397-1401
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Abstract

Triptolide, a traditional anti-inflammatory and anti-immunodepressive agent, has been reported to exert anti-neoplastic activity on several human tumor cell lines. This study investigates the pro-apoptotic function and the functional mechanism of triptolide on anaplastic thyroid carcinoma (ATC) cells. Experiments presented here demonstrated that triptolide had dose-dependent effects on cell viability of human ATC cell line TA-K cells through inducing cell apoptosis. In the molecular level, triptolide did not successfully initiate p53 signaling pathway, but downregulated the nuclear factor κB (NF-κB) pathway. Our studies suggest that triptolide functions as an effective apoptotic inducer in a p53-independent, but NF-κB-dependent mechanism, thus providing a promising agent for tumor types with p53 mutation/deletion.

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December 2009
Volume 22 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhu W, Hu H, Qiu P and Yan G: Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism . Oncol Rep 22: 1397-1401, 2009
APA
Zhu, W., Hu, H., Qiu, P., & Yan, G. (2009). Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism . Oncology Reports, 22, 1397-1401. https://doi.org/10.3892/or_00000580
MLA
Zhu, W., Hu, H., Qiu, P., Yan, G."Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism ". Oncology Reports 22.6 (2009): 1397-1401.
Chicago
Zhu, W., Hu, H., Qiu, P., Yan, G."Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism ". Oncology Reports 22, no. 6 (2009): 1397-1401. https://doi.org/10.3892/or_00000580