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Impaired immune function: An early marker for cancer cachexia

  • Authors:
    • Joyce Faber
    • Arjan P. Vos
    • Diane Kegler
    • Josep Argilés
    • Alessandro Laviano
    • Johan Garssen
    • Ardy Van Helvoort

  • View Affiliations

  • Published online on: December 1, 2009     https://doi.org/10.3892/or_00000581
  • Pages: 1403-1406
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Abstract

Cachexia and chronic inflammation are major challenges for cancer patients, leading to serious consequences. Accordingly, it is of high clinical relevance to identify early risk factors for optimal treatment, as these are currently not available. The present study demonstrates a strong decline in contact hypersensitivity, a parameter for cell-mediated immunity, in tumor-bearing cachectic mice. Interestingly, a significant reduction was already observed during the pre-cachectic state, reflecting an impaired immune function prior to weight loss. Extrapolating to the human setting, reduced immune competence of cancer patients could serve as an early marker for cancer cachexia, enabling an early supportive care strategy.

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Journal Cover

December 2009
Volume 22 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Faber J, Vos AP, Kegler D, Argilés J, Laviano A, Garssen J and Van Helvoort A: Impaired immune function: An early marker for cancer cachexia . Oncol Rep 22: 1403-1406, 2009
APA
Faber, J., Vos, A.P., Kegler, D., Argilés, J., Laviano, A., Garssen, J., & Van Helvoort, A. (2009). Impaired immune function: An early marker for cancer cachexia . Oncology Reports, 22, 1403-1406. https://doi.org/10.3892/or_00000581
MLA
Faber, J., Vos, A. P., Kegler, D., Argilés, J., Laviano, A., Garssen, J., Van Helvoort, A."Impaired immune function: An early marker for cancer cachexia ". Oncology Reports 22.6 (2009): 1403-1406.
Chicago
Faber, J., Vos, A. P., Kegler, D., Argilés, J., Laviano, A., Garssen, J., Van Helvoort, A."Impaired immune function: An early marker for cancer cachexia ". Oncology Reports 22, no. 6 (2009): 1403-1406. https://doi.org/10.3892/or_00000581