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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 23 Issue 1

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Article

Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery

  • Authors:
    • Hong-Yi Wang
    • Jing-Yu Zhang
    • Jian-Tao Cui
    • Xiao-Hui Tan
    • Wen-Mei Li
    • Jin Gu
    • You-Yong Lu

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P.R. China
  • Pages: 45-52
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000604
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Abstract

To investigate whether S100A14 and S100A4 expression correlates with metastatic potential and prognosis in colorectal cancer (CRC), we firstly used RT-PCR analysis to detect mRNA expression of S100A14 and S100A4 in 40 pairs of fresh tumor samples matched with adjacent normal tissues. We then evaluated the clinical significance of our findings with immunohistochemistry on 115 samples of formalin-fixed and paraffin-embedded tumors on tissue microarrays. Typically, we identified decreased S100A14 mRNA levels (52.5%, 21/40), and increased S100A4 mRNA levels (70.0%, 28/40) in primary CRC samples. In addition, down-regulated or absent S100A14 expression was detected in 56.5% of samples (65/115) and was correlated with poor differentiation (P=0.010). In contrast, overexpressed S100A4 was detected in 57.4% of samples (66/115) and was associated with lymph node metastasis (P=0.001). Simultaneous S100A14 low-expression and S100A4 high-expression was correlated with high CRC metastatic potential (P<0.001). Taken together, the signature derived from the combined expression status of S100A14 and S100A4 could be a valuable prognostic indicator in CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Zhang J, Cui J, Tan X, Li W, Gu J and Lu Y: Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery. Oncol Rep 23: 45-52, 2010.
APA
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., & Lu, Y. (2010). Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery. Oncology Reports, 23, 45-52. https://doi.org/10.3892/or_00000604
MLA
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., Lu, Y."Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23.1 (2010): 45-52.
Chicago
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., Lu, Y."Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23, no. 1 (2010): 45-52. https://doi.org/10.3892/or_00000604
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Zhang J, Cui J, Tan X, Li W, Gu J and Lu Y: Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery. Oncol Rep 23: 45-52, 2010.
APA
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., & Lu, Y. (2010). Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery. Oncology Reports, 23, 45-52. https://doi.org/10.3892/or_00000604
MLA
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., Lu, Y."Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23.1 (2010): 45-52.
Chicago
Wang, H., Zhang, J., Cui, J., Tan, X., Li, W., Gu, J., Lu, Y."Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23, no. 1 (2010): 45-52. https://doi.org/10.3892/or_00000604
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