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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 23 Issue 1

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Article

p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

  • Authors:
    • Yoshihiro Fujii
    • Takamitsu Kato
    • Nobuo Kubota
    • Akira Fujimori
    • Ohtsura Niwa
    • Ryuichi Okayasu

  • View Affiliations / Copyright

    Affiliations: Ibaraki Prefectural University of Health Sciences, Department of Radiological Sciences, Ibaraki 300-0394, Japan
  • Pages: 199-203
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000623
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Abstract

Inhibition of heat shock protein 90 (Hsp90) is an attractive modality for cancer therapy. Recent studies presented that an Hsp90 inhibitor, 17AAG (17-allylamino-17-demethoxygeldanamycin), enhanced tumor radio-sensitivity, while this was not observed in normal cells. One of the studies reported that the effect of this drug was only observed in tumor cells carrying the wild-type p53 gene, thus demonstrating p53-dependent tumor radio-sensitization by 17AAG. We have now tested the effects of 17AAG on two human lymphoblastoid cell lines from the same donor, TK6 cells with the wild-type p53 gene and WTK1 cells with the mutated p53 gene. The effects of 17AAG were tested at concentrations of 10 and 100 nM on various parameters, including growth inhibition of the cells, enhancement of radio-sensitivity by colony formation assay, apoptosis and chromosomal radio-sensitivity and abrogation of radiation induced G2/M checkpoint. When 100 nM 17AAG was applied, all of these parameters were enhanced in a similar fashion in both cell lines, indicating that the drug effect is p53-independent. Our results suggest that 17AAG is likely to be an effective sensitizer for radiotherapy, even on tumors with mutated p53.

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Copy and paste a formatted citation
Spandidos Publications style
Fujii Y, Kato T, Kubota N, Fujimori A, Niwa O and Okayasu R: p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Oncol Rep 23: 199-203, 2010.
APA
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., & Okayasu, R. (2010). p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Oncology Reports, 23, 199-203. https://doi.org/10.3892/or_00000623
MLA
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., Okayasu, R."p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin". Oncology Reports 23.1 (2010): 199-203.
Chicago
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., Okayasu, R."p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin". Oncology Reports 23, no. 1 (2010): 199-203. https://doi.org/10.3892/or_00000623
Copy and paste a formatted citation
x
Spandidos Publications style
Fujii Y, Kato T, Kubota N, Fujimori A, Niwa O and Okayasu R: p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Oncol Rep 23: 199-203, 2010.
APA
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., & Okayasu, R. (2010). p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Oncology Reports, 23, 199-203. https://doi.org/10.3892/or_00000623
MLA
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., Okayasu, R."p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin". Oncology Reports 23.1 (2010): 199-203.
Chicago
Fujii, Y., Kato, T., Kubota, N., Fujimori, A., Niwa, O., Okayasu, R."p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin". Oncology Reports 23, no. 1 (2010): 199-203. https://doi.org/10.3892/or_00000623
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