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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 23 Issue 1

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Article

Hypoxia activates heparanase expression in an NF-κB dependent manner

  • Authors:
    • Wujun Wu
    • Cheng'en Pan
    • Kewei Meng
    • Lin Zhao
    • Lixue Du
    • Qingguang Liu
    • Rong Lin

  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Shaanxi Provincial People's Hospital, Xi'an City 710068, P.R. China. wuwujun_xa@163.com
  • Pages: 255-261
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000631
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Abstract

Hypoxia was shown to increase tumor cell invasion into the extracellular matrix in vitro. This result suggests that heparanase (Hpa), one of the key enzymes involved in tumor invasion and metastasis, may be regulated by hypoxia. RT-PCR, Western blot and Matrigel invasive assays were used to study the regulation of Hpa under hypoxia in human pancreatic MIA PaCa-2 cancer cells. Compared with those in normoxia (20% O2), Hpa mRNA, protein and enzymatic activity levels, were up-regulated by a reduction in the oxygen level (1% O2). Invasion by tumor cells into the extracellular matrix was found to be significantly enhanced. A reduction in Hpa protein levels was observed when nuclear factor κB (NF-κB) activation was blocked by pyrrolidine dithiocarbamate. The levels of Hpa were also reduced when Hpa was inhibited by an Hpa-specific antisense oligonucleotide. The MMP-9 mRNA, protein and gelatinase B activity levels in supernatants decreased significantly when Hpa was inhibited. We conclude that up-regulation of Hpa by hypoxia is NF-κB-dependent in MIA PaCa-2 cells and inhibition of Hpa reduces MMP-9 activity. This reduction in MMP-9 activity may be an important mechanism in tumor metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Pan C, Meng K, Zhao L, Du L, Liu Q and Lin R: Hypoxia activates heparanase expression in an NF-κB dependent manner. Oncol Rep 23: 255-261, 2010.
APA
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., & Lin, R. (2010). Hypoxia activates heparanase expression in an NF-κB dependent manner. Oncology Reports, 23, 255-261. https://doi.org/10.3892/or_00000631
MLA
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., Lin, R."Hypoxia activates heparanase expression in an NF-κB dependent manner". Oncology Reports 23.1 (2010): 255-261.
Chicago
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., Lin, R."Hypoxia activates heparanase expression in an NF-κB dependent manner". Oncology Reports 23, no. 1 (2010): 255-261. https://doi.org/10.3892/or_00000631
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Pan C, Meng K, Zhao L, Du L, Liu Q and Lin R: Hypoxia activates heparanase expression in an NF-κB dependent manner. Oncol Rep 23: 255-261, 2010.
APA
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., & Lin, R. (2010). Hypoxia activates heparanase expression in an NF-κB dependent manner. Oncology Reports, 23, 255-261. https://doi.org/10.3892/or_00000631
MLA
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., Lin, R."Hypoxia activates heparanase expression in an NF-κB dependent manner". Oncology Reports 23.1 (2010): 255-261.
Chicago
Wu, W., Pan, C., Meng, K., Zhao, L., Du, L., Liu, Q., Lin, R."Hypoxia activates heparanase expression in an NF-κB dependent manner". Oncology Reports 23, no. 1 (2010): 255-261. https://doi.org/10.3892/or_00000631
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