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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2010 Volume 23 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 23 Issue 3

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Review

Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review)

  • Authors:
    • Ana Maria Vladareanu
    • Carsten Müller-Tidow
    • Horia Bumbea
    • Sinziana Radesi

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Emergency Universitary Hospital Bucharest, 050098 Bucharest, Romania. anamariavladareanu@yahoo.com
  • Pages: 595-604
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/or_00000674
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Abstract

The Philadelphia negative chronic myeloproliferative neoplasms are hematological disorders with several diagnostic challenges. Due to recent molecular findings, the WHO classification of Tumors of Hematopoietic and Lymphoid Tissue 2008 reorganized the field of chronic myeloproliferative diseases. Thus, specific molecular markers provide important information for current diagnostic strategies. This review highlights the important diagnostic tools in classical and atypical myeloproliferative neoplasms mainly the JAK2V617F mutation, the Mpl receptor, Polycythemia rubra vera 1 (PRV1), platelet-derived growth-factor receptor α (PDGFRA), platelet-derived growth-factor receptor β (PDGFRB), fibroblast growth-factor receptor 1 (FGFR1) and c-kit tyrosine kinase. A description of the origin, clinical correlations and role in diagnosis and therapy is provided for each of these molecular markers.

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Copy and paste a formatted citation
Spandidos Publications style
Vladareanu AM, Müller-Tidow C, Bumbea H and Radesi S: Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review). Oncol Rep 23: 595-604, 2010.
APA
Vladareanu, A.M., Müller-Tidow, C., Bumbea, H., & Radesi, S. (2010). Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review). Oncology Reports, 23, 595-604. https://doi.org/10.3892/or_00000674
MLA
Vladareanu, A. M., Müller-Tidow, C., Bumbea, H., Radesi, S."Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review)". Oncology Reports 23.3 (2010): 595-604.
Chicago
Vladareanu, A. M., Müller-Tidow, C., Bumbea, H., Radesi, S."Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review)". Oncology Reports 23, no. 3 (2010): 595-604. https://doi.org/10.3892/or_00000674
Copy and paste a formatted citation
x
Spandidos Publications style
Vladareanu AM, Müller-Tidow C, Bumbea H and Radesi S: Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review). Oncol Rep 23: 595-604, 2010.
APA
Vladareanu, A.M., Müller-Tidow, C., Bumbea, H., & Radesi, S. (2010). Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review). Oncology Reports, 23, 595-604. https://doi.org/10.3892/or_00000674
MLA
Vladareanu, A. M., Müller-Tidow, C., Bumbea, H., Radesi, S."Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review)". Oncology Reports 23.3 (2010): 595-604.
Chicago
Vladareanu, A. M., Müller-Tidow, C., Bumbea, H., Radesi, S."Molecular markers guide diagnosis and treatment in Philadelphia chromosome-negative myeloproliferative disorders (Review)". Oncology Reports 23, no. 3 (2010): 595-604. https://doi.org/10.3892/or_00000674
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