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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2010 Volume 23 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas

  • Authors:
    • Rui Niimi
    • Akihiko Matsumine
    • Takahiro Iino
    • Tetsuya Murata
    • Ken Shintani
    • Shigeto Nakazora
    • Tomoki Nakamura
    • Yudai Uehara
    • Katsuyuki Kusuzaki
    • Tetsu Akiyama
    • Atsumasa Uchida

  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514-8507, Japan
  • Pages: 631-638
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/or_00000678
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Abstract

The human homologue of Drosophila disc large tumor suppressor protein (hDlg) is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported in several cancer types. However, the expression of hDlg in soft-tissue sarcomas has not yet been reported. We examined the expression of hDlg immunohistochemically in 46 specimens of malignant fibrous histiocytoma (MFH). The expression of hDlg was negative in 19 specimens, weak in 4, moderate in 16, and strong in 7. The patients with a weak or negative expression of hDlg had a significantly shorter metastasis-free survival rate and disease-free survival rate in comparison with those with a strong or moderate expression in both univariate analysis (p=0.0287 and 0.0237, respectively; log-rank test) and multivariate analysis (p=0.0087 and 0.0126, respectively; Cox proportional hazards regression model). Moreover, the patients with a weak or negative expression of hDlg had a significantly shorter overall survival rate in comparison with those with a strong or moderate expression in a univariate analysis (p=0.0214; log-rank test). This is the first report to demonstrate that a reduced expression of hDlg protein is an independent negative prognostic factor for MFH.

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Copy and paste a formatted citation
Spandidos Publications style
Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T, Uehara Y, Kusuzaki K, Akiyama T, Akiyama T, et al: The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. Oncol Rep 23: 631-638, 2010.
APA
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S. ... Uchida, A. (2010). The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. Oncology Reports, 23, 631-638. https://doi.org/10.3892/or_00000678
MLA
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S., Nakamura, T., Uehara, Y., Kusuzaki, K., Akiyama, T., Uchida, A."The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas". Oncology Reports 23.3 (2010): 631-638.
Chicago
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S., Nakamura, T., Uehara, Y., Kusuzaki, K., Akiyama, T., Uchida, A."The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas". Oncology Reports 23, no. 3 (2010): 631-638. https://doi.org/10.3892/or_00000678
Copy and paste a formatted citation
x
Spandidos Publications style
Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T, Uehara Y, Kusuzaki K, Akiyama T, Akiyama T, et al: The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. Oncol Rep 23: 631-638, 2010.
APA
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S. ... Uchida, A. (2010). The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. Oncology Reports, 23, 631-638. https://doi.org/10.3892/or_00000678
MLA
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S., Nakamura, T., Uehara, Y., Kusuzaki, K., Akiyama, T., Uchida, A."The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas". Oncology Reports 23.3 (2010): 631-638.
Chicago
Niimi, R., Matsumine, A., Iino, T., Murata, T., Shintani, K., Nakazora, S., Nakamura, T., Uehara, Y., Kusuzaki, K., Akiyama, T., Uchida, A."The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas". Oncology Reports 23, no. 3 (2010): 631-638. https://doi.org/10.3892/or_00000678
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