Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma

  • Authors:
    • Feng Gu
    • Yongjie Ma
    • Zuping Zhang
    • Jinghui Zhao
    • Hisayuki Kobayashi
    • Lun Zhang
    • Li Fu
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/or_00000683
  • Pages: 671-676
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Abstract

Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma (HNSCC), but cisplatin resistance in HNSCC is still a serious problem in clinic. The reasons why patients fail chemotherapy are unclear. We examined 25 HNSCC patients who were all tested for cisplatin sensitivity by CD-DST (collagen gel droplet embedded culture-drug sensitivity) method and expression of Stat3 and Notch1. We found that high expression levels of Stat3 and Notch1 were closely associated with cisplatin resistance respectively (P=0.014, P=0.000). In addition, cisplatin resistance of HNSCC was decreased after inhibition of Stat3 or Notch signaling in vitro. Our results provide first evidence that both high Stat3 and Notch1 expression are associated with cisplatin resistance in HNSCC patients, supporting the hypothesis that co-activation of Stat3 and Notch1 by their crosstalk induces the reprogrammed survival pathways in HNSCC responding to chemotherapy.

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March 2010
Volume 23 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gu F, Ma Y, Zhang Z, Zhao J, Kobayashi H, Zhang L and Fu L: Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep 23: 671-676, 2010
APA
Gu, F., Ma, Y., Zhang, Z., Zhao, J., Kobayashi, H., Zhang, L., & Fu, L. (2010). Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncology Reports, 23, 671-676. https://doi.org/10.3892/or_00000683
MLA
Gu, F., Ma, Y., Zhang, Z., Zhao, J., Kobayashi, H., Zhang, L., Fu, L."Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma". Oncology Reports 23.3 (2010): 671-676.
Chicago
Gu, F., Ma, Y., Zhang, Z., Zhao, J., Kobayashi, H., Zhang, L., Fu, L."Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma". Oncology Reports 23, no. 3 (2010): 671-676. https://doi.org/10.3892/or_00000683