Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas

  • Authors:
    • Motoshi Kanai
    • Jun-Ichi Hamada
    • Minoru Takada
    • Toshimichi Asano
    • Katsuhiko Murakawa
    • Yoko Takahashi
    • Taichi Murai
    • Mitsuhiro Tada
    • Masaki Miyamoto
    • Satoshi Kondo
    • Tetsuya Moriuchi
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/or_00000706
  • Pages: 843-851
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Abstract

HOX genes are known as master regulator genes which give cells positional information in embryogenesis. In this study, we compared the expression patterns of 39 HOX genes among human colorectal carcinomas from the right large intestine (cecum, ascending and transverse colon), those from the left large intestine (discending and sigmoid colon, and rectum) and hepatocellular carcinoma. The expression levels of each HOX gene were quantified by analysis based on the real-time RT-PCR. The expression patterns of HOX genes in colorectal and hepatocellular carcinoma tissues differed from those in their normal or non-cancerous tissues. Between the tumor tissues in the right-side large intestine and those in the left-side, different HOX genes were expressed in association with cancer. Further, the expression levels of HOXD8 in liver-metastatic tissues of colorectal carcinomas were as low as in non-cancerous liver tissues, and were significantly lower than those in the primary tissues. These results suggest that dysregulated expressions of HOX genes play an important role in carcinogenesis and malignant progression of colorectal and hepatocellular carcinomas.

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March 2010
Volume 23 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kanai M, Hamada J, Takada M, Asano T, Murakawa K, Takahashi Y, Murai T, Tada M, Miyamoto M, Kondo S, Kondo S, et al: Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas. Oncol Rep 23: 843-851, 2010
APA
Kanai, M., Hamada, J., Takada, M., Asano, T., Murakawa, K., Takahashi, Y. ... Moriuchi, T. (2010). Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas. Oncology Reports, 23, 843-851. https://doi.org/10.3892/or_00000706
MLA
Kanai, M., Hamada, J., Takada, M., Asano, T., Murakawa, K., Takahashi, Y., Murai, T., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas". Oncology Reports 23.3 (2010): 843-851.
Chicago
Kanai, M., Hamada, J., Takada, M., Asano, T., Murakawa, K., Takahashi, Y., Murai, T., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas". Oncology Reports 23, no. 3 (2010): 843-851. https://doi.org/10.3892/or_00000706