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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2010 Volume 23 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review)

  • Authors:
    • Anna Chiarini
    • James F. Whitfield
    • Raffaella Pacchiana
    • Maddalena Marconi
    • Ubaldo Armato
    • Ilaria Dal Prà

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical and Surgical Sciences, University of Verona Medical School, I-37134 Verona, Italy
  • Pages: 887-892
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/or_00000711
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Abstract

Perylenequinones that generate reactive oxygen species (ROS) when illuminated with visible light have been recommended as photodynamic chemotherapeutic agents. One of these is calphostin C (CalC), the action of the photo-activated derivative of which, CalCφE, has been ascribed to its ability to selectively and irreversibly inhibit protein kinase Cs (PKCs). But recent results of experiments with neoplastic rat fibroblasts and human breast and uterine cervix cancer cells have revealed that the action of CalCφE involves more than PKC inhibition. Besides suppressing PKC activity, CalCφE rapidly causes endoplasmic reticulum (ER) stress in breast cancer cells and the selective complete oxidation and proteasomal destruction of the functionally essential nuclear envelope protein lamin B1, in human cervical carcinoma (HCC) cells and neoplastic rat fibroblasts. When these lamin B1-lacking cells are placed in the dark, cytoplasmic membrane-linked PKC activities suddenly rebound and apoptogenesis is initiated as indicated by the immediate release of cytochrome c from mitochondria and later on the activation of caspases. Hence, CalCφE is a photodynamic cytocidal agent attacking multiple targets in cancer cells and it would be worth determining, even for their best applicative use, whether other perylenequinones also share the so far unexpectedly complex deadly properties of the CalCφE.

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Copy and paste a formatted citation
Spandidos Publications style
Chiarini A, Whitfield JF, Pacchiana R, Marconi M, Armato U and Dal Prà I: Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) . Oncol Rep 23: 887-892, 2010.
APA
Chiarini, A., Whitfield, J.F., Pacchiana, R., Marconi, M., Armato, U., & Dal Prà, I. (2010). Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) . Oncology Reports, 23, 887-892. https://doi.org/10.3892/or_00000711
MLA
Chiarini, A., Whitfield, J. F., Pacchiana, R., Marconi, M., Armato, U., Dal Prà, I."Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) ". Oncology Reports 23.4 (2010): 887-892.
Chicago
Chiarini, A., Whitfield, J. F., Pacchiana, R., Marconi, M., Armato, U., Dal Prà, I."Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) ". Oncology Reports 23, no. 4 (2010): 887-892. https://doi.org/10.3892/or_00000711
Copy and paste a formatted citation
x
Spandidos Publications style
Chiarini A, Whitfield JF, Pacchiana R, Marconi M, Armato U and Dal Prà I: Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) . Oncol Rep 23: 887-892, 2010.
APA
Chiarini, A., Whitfield, J.F., Pacchiana, R., Marconi, M., Armato, U., & Dal Prà, I. (2010). Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) . Oncology Reports, 23, 887-892. https://doi.org/10.3892/or_00000711
MLA
Chiarini, A., Whitfield, J. F., Pacchiana, R., Marconi, M., Armato, U., Dal Prà, I."Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) ". Oncology Reports 23.4 (2010): 887-892.
Chicago
Chiarini, A., Whitfield, J. F., Pacchiana, R., Marconi, M., Armato, U., Dal Prà, I."Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review) ". Oncology Reports 23, no. 4 (2010): 887-892. https://doi.org/10.3892/or_00000711
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