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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC

  • Authors:
    • Sotai Kimura
    • Seiji Naganuma
    • Dai Susuki
    • Yasuo Hirono
    • Akio Yamaguchi
    • Shigeharu Fujieda
    • Kazuo Sano
    • Hiroshi Itoh

  • View Affiliations / Copyright

    Affiliations: Division of Tumor Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
  • Pages: 1625-1633
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000804
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Abstract

MicroRNAs (miRNAs) are non-coding small RNAs that regulate cell proliferation and functions by interfering with the translation of target mRNAs. Altered expression of miRNA is known to induce various human malignancies. We examined the expression of miRNAs in squamous cell carcinoma of human head and neck (HNSCC) and esophagus (ESCC), compared to that in normal squamous epithelia as well as malignancies of other organs. Microarray analysis showed up-regulation of miR-21, miR-16 and miR-30a-5p in HNSCC and ESCC cell lines compared to normal squamous epithelial cell lines, and consistent high expression of miR-205 and let-7a in both normal and malignant squamous epithelial cell lines. Validation study using real-time quantitative RT-PCR in formalin-fixed paraffin-embedded cancer tissues and paired normal epithelia obtained by Laser-captured microdissection revealed that miR-205 showed highest expression in both malignant and benign squamous epithelia, although it was less expressed in cell lines and tissues other than squamous epithelia. MiR-21, which is an oncogenic miRNA in various malignancies, was also up-regulated in HNSCC and ESCC compared to paired normal squamous epithelia. These results suggest that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in HNSCC and ESCC.

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Copy and paste a formatted citation
Spandidos Publications style
Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K and Itoh H: Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC . Oncol Rep 23: 1625-1633, 2010.
APA
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S. ... Itoh, H. (2010). Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC . Oncology Reports, 23, 1625-1633. https://doi.org/10.3892/or_00000804
MLA
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S., Sano, K., Itoh, H."Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC ". Oncology Reports 23.6 (2010): 1625-1633.
Chicago
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S., Sano, K., Itoh, H."Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC ". Oncology Reports 23, no. 6 (2010): 1625-1633. https://doi.org/10.3892/or_00000804
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K and Itoh H: Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC . Oncol Rep 23: 1625-1633, 2010.
APA
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S. ... Itoh, H. (2010). Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC . Oncology Reports, 23, 1625-1633. https://doi.org/10.3892/or_00000804
MLA
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S., Sano, K., Itoh, H."Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC ". Oncology Reports 23.6 (2010): 1625-1633.
Chicago
Kimura, S., Naganuma, S., Susuki, D., Hirono, Y., Yamaguchi, A., Fujieda, S., Sano, K., Itoh, H."Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC ". Oncology Reports 23, no. 6 (2010): 1625-1633. https://doi.org/10.3892/or_00000804
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