The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma

  • Authors:
    • Sakae Nagaoka
    • Takafumi Yoshida
    • Junji Akiyoshi
    • Jun Akiba
    • Takao Hisamoto
    • Yoko Yoshida
    • Mitsuhiko Abe
    • Hironori Koga
    • Takuji Toirimura
    • Takato Ueno
    • Michio Sata
  • View Affiliations

  • Published online on: June 1, 2010     https://doi.org/10.3892/or_00000807
  • Pages: 1647-1654
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Angiogenesis plays crucial roles in development and progression of hepatocellular carcinoma (HCC). Placenta growth factor (PLGF), belonging to vascular endothelial growth factor (VEGF) family, is involved in angiogenesis associated with cancer. Soluble VEGF receptor-1 (sVEGFR1) has been thought to be an intrinsic negative regulator for PLGF. We investigated whether serum PLGF and serum sVEGFR1 is associated with prognosis of HCC. Serum PLGF and sVEGFR1 levels were measured in 145 patients with HCC using enzyme-linked immunosorbent assay. The levels of these factors and the ratio of PLGF to sVEGFR1 were analyzed in relation with clinical parameters. The higher level of sVEGFR1 and the lower ratio of PLGF/sVEGFR1 were significantly associated with poor survival in HCC. Cox regression analysis revealed that the lower ratio of PLGF/sVEGFR1 independently correlated to prognosis of patients with HCC. The ratio of PLGF/sVEGFR1 was independent prognostic indicator for HCC. The ratio of PLGF/sVEGFR1 should be addressed in anti-angiogenic therapy for HCC.

Related Articles

Journal Cover

June 2010
Volume 23 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nagaoka S, Yoshida T, Akiyoshi J, Akiba J, Hisamoto T, Yoshida Y, Abe M, Koga H, Toirimura T, Ueno T, Ueno T, et al: The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncol Rep 23: 1647-1654, 2010
APA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y. ... Sata, M. (2010). The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncology Reports, 23, 1647-1654. https://doi.org/10.3892/or_00000807
MLA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23.6 (2010): 1647-1654.
Chicago
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23, no. 6 (2010): 1647-1654. https://doi.org/10.3892/or_00000807