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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma

  • Authors:
    • Sakae Nagaoka
    • Takafumi Yoshida
    • Junji Akiyoshi
    • Jun Akiba
    • Takao Hisamoto
    • Yoko Yoshida
    • Mitsuhiko Abe
    • Hironori Koga
    • Takuji Toirimura
    • Takato Ueno
    • Michio Sata

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy and Center of the 21st Century COE Program for Medical Science, Kurume University School of Medicine, Kurume 830-0011, Japan
  • Pages: 1647-1654
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000807
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Abstract

Angiogenesis plays crucial roles in development and progression of hepatocellular carcinoma (HCC). Placenta growth factor (PLGF), belonging to vascular endothelial growth factor (VEGF) family, is involved in angiogenesis associated with cancer. Soluble VEGF receptor-1 (sVEGFR1) has been thought to be an intrinsic negative regulator for PLGF. We investigated whether serum PLGF and serum sVEGFR1 is associated with prognosis of HCC. Serum PLGF and sVEGFR1 levels were measured in 145 patients with HCC using enzyme-linked immunosorbent assay. The levels of these factors and the ratio of PLGF to sVEGFR1 were analyzed in relation with clinical parameters. The higher level of sVEGFR1 and the lower ratio of PLGF/sVEGFR1 were significantly associated with poor survival in HCC. Cox regression analysis revealed that the lower ratio of PLGF/sVEGFR1 independently correlated to prognosis of patients with HCC. The ratio of PLGF/sVEGFR1 was independent prognostic indicator for HCC. The ratio of PLGF/sVEGFR1 should be addressed in anti-angiogenic therapy for HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Nagaoka S, Yoshida T, Akiyoshi J, Akiba J, Hisamoto T, Yoshida Y, Abe M, Koga H, Toirimura T, Ueno T, Ueno T, et al: The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncol Rep 23: 1647-1654, 2010.
APA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y. ... Sata, M. (2010). The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncology Reports, 23, 1647-1654. https://doi.org/10.3892/or_00000807
MLA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23.6 (2010): 1647-1654.
Chicago
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23, no. 6 (2010): 1647-1654. https://doi.org/10.3892/or_00000807
Copy and paste a formatted citation
x
Spandidos Publications style
Nagaoka S, Yoshida T, Akiyoshi J, Akiba J, Hisamoto T, Yoshida Y, Abe M, Koga H, Toirimura T, Ueno T, Ueno T, et al: The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncol Rep 23: 1647-1654, 2010.
APA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y. ... Sata, M. (2010). The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma . Oncology Reports, 23, 1647-1654. https://doi.org/10.3892/or_00000807
MLA
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23.6 (2010): 1647-1654.
Chicago
Nagaoka, S., Yoshida, T., Akiyoshi, J., Akiba, J., Hisamoto, T., Yoshida, Y., Abe, M., Koga, H., Toirimura, T., Ueno, T., Sata, M."The ratio of serum placenta growth factor to soluble vascular endothelial growth factor receptor-1 predicts the prognosis of hepatocellular carcinoma ". Oncology Reports 23, no. 6 (2010): 1647-1654. https://doi.org/10.3892/or_00000807
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