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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid

  • Authors:
    • Young-Min Cho
    • Ae-Hee Yang
    • Bu-Yeon Kim
    • Young-Hoon Han

  • View Affiliations / Copyright

    Affiliations: Division of Radiation Cancer Biology, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea
  • Pages: 1715-1720
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000816
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Abstract

Retinoid X receptor-α (RXRα) fragments are known to be produced in some cancer cells by proteolytic cleavage. Previous finding that ligand binding domain (LBD) fragment of RXRα specifically inhibits retinoic acid receptor-γ (RARγ) activity led us to investigate the functional role of RXRα LBD fragment in radiosensitization by retinoic acid (RA). Ectopic expression of RXRα LBD fragment in cells that do not have a detectable endogenous RXRα LBD fragment, blocked synergistic radiosensitizing action of RA, as determined by growth inhibition, cell death and colony formation assays. However, H460 cell, which has an endogenous RXRα LBD fragment, was not radiosensitized by RA regardless of the ectopic RXRα LBD fragment expression. These results were paralleled with the pattern of p21Waf1/Cip1 induction by the treatment of RA in combination with ionizing radiation (IR). Taken together, we hypothesize that the RXRα LBD fragment may act as a negative regulator of radiosensitizing effect of RA by restricting the RARγ-mediated biological response to RA.

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Copy and paste a formatted citation
Spandidos Publications style
Cho Y, Yang A, Kim B and Han Y: The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid . Oncol Rep 23: 1715-1720, 2010.
APA
Cho, Y., Yang, A., Kim, B., & Han, Y. (2010). The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid . Oncology Reports, 23, 1715-1720. https://doi.org/10.3892/or_00000816
MLA
Cho, Y., Yang, A., Kim, B., Han, Y."The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid ". Oncology Reports 23.6 (2010): 1715-1720.
Chicago
Cho, Y., Yang, A., Kim, B., Han, Y."The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid ". Oncology Reports 23, no. 6 (2010): 1715-1720. https://doi.org/10.3892/or_00000816
Copy and paste a formatted citation
x
Spandidos Publications style
Cho Y, Yang A, Kim B and Han Y: The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid . Oncol Rep 23: 1715-1720, 2010.
APA
Cho, Y., Yang, A., Kim, B., & Han, Y. (2010). The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid . Oncology Reports, 23, 1715-1720. https://doi.org/10.3892/or_00000816
MLA
Cho, Y., Yang, A., Kim, B., Han, Y."The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid ". Oncology Reports 23.6 (2010): 1715-1720.
Chicago
Cho, Y., Yang, A., Kim, B., Han, Y."The cleavage fragment of retinoid X receptor-α ligand binding domain inhibits radiosensitization by retinoic acid ". Oncology Reports 23, no. 6 (2010): 1715-1720. https://doi.org/10.3892/or_00000816
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